DegronMD

Uniprot ID: Q8TDG4

Source protein: Helicase POLQ-like

Source gene: HELQ

Class: DEG_SPOP_SBC_1

Location: 253:257

E3 ligase: SPOP

DEGRON score: 0.5893

ASA_SCORE: 88.38

COIL: 0.763

CONS_SCORE: 0.2708

DSS_SCORE: 0.7346

HELIX: 0.1574

FCONS_SCORE: 0.9982

RIG_SCORE: 0.6476

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R262I	TCGA-AP-A1DV	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.1944
p.R262I	DO43186	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1944
p.N246K	TCGA-BS-A0UF	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.1389
p.N246K	DO41488	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1389
p.M259V	DO222973	BTCA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.2778
p.P243S	DO223419	CLLE	ICGC	VRTSS	DEG_SPOP_SBC_1	0.0556
p.N246S	DO234192	ESAD	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1389
p.S251P	SIDM01314	Colorectal Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.2778
p.D247N	SIDM00319	Melanoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.1667
p.D247N	ACH-001704	Skin Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	0.1667
p.D247N	VMRC-MELG	skin	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.1667
p.D258Y	SIDM00963	Breast Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.3056
p.D258Y	ACH-000927	Breast Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	0.3056
p.D258Y	BT-474	breast	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13439	Golgin subfamily A member 4	DEG_SPOP_SBC_1	94:98	VRTSS	SPOP	0.9897	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	376:380	VRTSS	SPOP	0.996	More...
Q8TDG4	Helicase POLQ-like	DEG_SPOP_SBC_1	253:257	VRTSS	SPOP	0.5893	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9817:9821	VRTSS	SPOP	0.8575	More...
Q8WY36	HMG box transcription factor BBX	DEG_SPOP_SBC_1	511:515	VRTSS	SPOP	0.9823	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	487:491	VRTSS	SPOP	0.7285	More...
Q8TE59	A disintegrin and metalloproteinase with thrombospondin motifs 19	DEG_SPOP_SBC_1	702:706	VRTSS	SPOP	0.6468	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	310:314	VRTSS	SPOP	0.9965	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SPOP_SBC_1	161:165	VRTSS	SPOP	0.7782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons