DegronMD - Q8TE59(ADAMTS19)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q696E	TCGA-A5-A0GP	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.1667
p.Q696E	DO41109	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.1667
p.T704P	TCGA-A5-A2K5	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation altering degron motif	0.7031
p.T704P	TCGA-CD-A48C	STAD	TCGA	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation altering degron motif	0.7031
p.T704P	DO47912	STAD	ICGC	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation altering degron motif	0.7031
p.T704P	DO41379	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation altering degron motif	0.7031
p.R693T	TCGA-CR-7365	HNSC	TCGA	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.0833
p.R693T	DO15991	HNSC	ICGC	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.0833
p.R693K	TCGA-DA-A3F8	SKCM	TCGA	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.0833
p.R693K	DO37418	SKCM	ICGC	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.0833
p.A715P	TCGA-QB-AA9O	SKCM	TCGA	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.0833
p.A715P	DO51267	SKCM	ICGC	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.0833
p.L711R	TCGA-RD-A7C1	STAD	TCGA	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.1944
p.L711R	TCGA-X8-AAAR	ESCA	TCGA	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.1944
p.L711R	DO233698	GACA	ICGC	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.1944
p.L711R	DO228599	PRAD	ICGC	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.1944
p.L711R	DO50132	STAD	ICGC	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.1944
p.A705S	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation altering degron motif	0.7588
p.A705S	VMRC-LCD	lung	COSMIC	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation altering degron motif	0.7588
p.A699S	ACH-001233	Lung Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.25
p.A699S	VMRC-LCD	lung	COSMIC	VRTSS	DEG_SPOP_SBC_1	702:706	Mutation rewiring degron network	0.25

Kaplan plot for ADAMTS19 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAMTS19

UniProt ID: Q8TE59

Entrez ID: 171019

Protein name: A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAM-TS 19) (ADAM-TS19) (ADAMTS-19) (EC 3.4.24.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAMTS19 in