DegronMD

Uniprot ID: Q8TE59

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 19

Source gene: ADAMTS19

Class: DEG_SPOP_SBC_1

Location: 702:706

E3 ligase: SPOP

DEGRON score: 0.6468

ASA_SCORE: 88.18

COIL: 0.9304

CONS_SCORE: 0.3886

DSS_SCORE: 0.1917

HELIX: 0.0512

FCONS_SCORE: 0.7497

RIG_SCORE: 0.746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q696E	TCGA-A5-A0GP	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.1667
p.Q696E	DO41109	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1667
p.T704P	TCGA-A5-A2K5	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.7031
p.T704P	TCGA-CD-A48C	STAD	TCGA	VRTSS	DEG_SPOP_SBC_1	0.7031
p.T704P	DO47912	STAD	ICGC	VRTSS	DEG_SPOP_SBC_1	0.7031
p.T704P	DO41379	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.7031
p.R693T	TCGA-CR-7365	HNSC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.0833
p.R693T	DO15991	HNSC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.R693K	TCGA-DA-A3F8	SKCM	TCGA	VRTSS	DEG_SPOP_SBC_1	0.0833
p.R693K	DO37418	SKCM	ICGC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.A715P	TCGA-QB-AA9O	SKCM	TCGA	VRTSS	DEG_SPOP_SBC_1	0.0833
p.A715P	DO51267	SKCM	ICGC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.L711R	TCGA-RD-A7C1	STAD	TCGA	VRTSS	DEG_SPOP_SBC_1	0.1944
p.L711R	TCGA-X8-AAAR	ESCA	TCGA	VRTSS	DEG_SPOP_SBC_1	0.1944
p.L711R	DO233698	GACA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1944
p.L711R	DO228599	PRAD	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1944
p.L711R	DO50132	STAD	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1944
p.A705S	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.7588
p.A705S	VMRC-LCD	lung	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.7588
p.A699S	ACH-001233	Lung Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	0.25
p.A699S	VMRC-LCD	lung	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13439	Golgin subfamily A member 4	DEG_SPOP_SBC_1	94:98	VRTSS	SPOP	0.9897	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	376:380	VRTSS	SPOP	0.996	More...
Q8TDG4	Helicase POLQ-like	DEG_SPOP_SBC_1	253:257	VRTSS	SPOP	0.5893	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9817:9821	VRTSS	SPOP	0.8575	More...
Q8WY36	HMG box transcription factor BBX	DEG_SPOP_SBC_1	511:515	VRTSS	SPOP	0.9823	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	487:491	VRTSS	SPOP	0.7285	More...
Q8TE59	A disintegrin and metalloproteinase with thrombospondin motifs 19	DEG_SPOP_SBC_1	702:706	VRTSS	SPOP	0.6468	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	310:314	VRTSS	SPOP	0.9965	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SPOP_SBC_1	161:165	VRTSS	SPOP	0.7782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons