DegronMD

Uniprot ID: Q7Z6G8

Source protein: Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Source gene: ANKS1B

Class: DEG_SPOP_SBC_1

Location: 376:380

E3 ligase: SPOP

DEGRON score: 0.996

ASA_SCORE: 79.52

COIL: 0.8646

CONS_SCORE: 0.3772

DSS_SCORE: 0.5832

HELIX: 0.078

FCONS_SCORE: 1.1313

RIG_SCORE: 0.671

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G369R	TCGA-34-7107	LUSC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.1389
p.G369R	DO26449	LUSC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1389
p.Q374H	TCGA-AP-A1DV	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.2778
p.Q374H	DO43186	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.2778
p.E367K	TCGA-EE-A29D	SKCM	TCGA	VRTSS	DEG_SPOP_SBC_1	0.0833
p.E367K	DO38123	SKCM	ICGC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.R377I	TCGA-F5-6814	READ	TCGA	VRTSS	DEG_SPOP_SBC_1	0.6991
p.R377I	DO36556	READ	ICGC	VRTSS	DEG_SPOP_SBC_1	0.6991
p.I382V	TCGA-FI-A2F4	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.2778
p.I382V	DO43434	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.2778
p.E366K	TCGA-FR-A726	SKCM	TCGA	VRTSS	DEG_SPOP_SBC_1	0.0556
p.E366K	DO48665	SKCM	ICGC	VRTSS	DEG_SPOP_SBC_1	0.0556
p.E366D	TCGA-PG-A915	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.0556
p.E366D	DO52422	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.0556
p.K370E	DO223109	ESCA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.2778
p.K370E	DO233199	GACA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.2778
p.L368R	DO228676	GACA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1111
p.G372R	DO222653	MELA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.2222
p.V389A	SIDM00588	Oral Cavity Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00373	Endometrial Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00330	Neuroblastoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00496	Thyroid Gland Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00157	Neuroblastoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00553	Acute Myeloid Leukemia	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00002	Neuroblastoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00571	Pancreatic Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00466	Ovarian Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00619	Thyroid Gland Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00351	Oral Cavity Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM01045	Endometrial Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00585	Hepatocellular Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM01180	Hepatocellular Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00498	Colorectal Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM01146	Gastric Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00576	Acute Myeloid Leukemia	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00397	Acute Myeloid Leukemia	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00655	Other Solid Cancers	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00271	Gastric Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00368	Small Cell Lung Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00560	Gastric Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00575	Glioma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00168	Head and Neck Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM01470	Acute Myeloid Leukemia	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM01770	Gastric Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM01368	Gastric Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM00008	Ovarian Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM01347	Ovarian Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM01690	Plasma Cell Myeloma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM01658	Unknown	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM01685	B-Lymphoblastic Leukemia	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM01473	Plasma Cell Myeloma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.V389A	SIDM01391	Neuroblastoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.L368F	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.1111
p.L368F	ACH-000917	Esophageal Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	0.1111
p.L368F	TE-4	oesophagus	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.1111
p.K366N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.0556
p.K366N	NB17	autonomic_ganglia	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.0556
p.A375T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.3056
p.E380K	NCI-H2342	lung	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.7022
p.G383R	MZ7-mel	skin	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.25
p.S370T	C-4-I	cervix	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.2778
p.M367I	A388	skin	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.0833
p.A379S	H513	pleura	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.7588
p.K377I	HCC-44	lung	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.7531
p.H387Y	LNCaP-Clone-FGC	prostate	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.1389
p.E377K	NCI-H2452	pleura	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.7022
p.E377K	SNU-61	large_intestine	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.7022
p.R381C	HT-115	large_intestine	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.3056
p.R383S	CCK-81	large_intestine	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.25
p.I370M	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.2778
p.Q377H	C-4-I	cervix	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13439	Golgin subfamily A member 4	DEG_SPOP_SBC_1	94:98	VRTSS	SPOP	0.9897	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	376:380	VRTSS	SPOP	0.996	More...
Q8TDG4	Helicase POLQ-like	DEG_SPOP_SBC_1	253:257	VRTSS	SPOP	0.5893	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9817:9821	VRTSS	SPOP	0.8575	More...
Q8WY36	HMG box transcription factor BBX	DEG_SPOP_SBC_1	511:515	VRTSS	SPOP	0.9823	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	487:491	VRTSS	SPOP	0.7285	More...
Q8TE59	A disintegrin and metalloproteinase with thrombospondin motifs 19	DEG_SPOP_SBC_1	702:706	VRTSS	SPOP	0.6468	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	310:314	VRTSS	SPOP	0.9965	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SPOP_SBC_1	161:165	VRTSS	SPOP	0.7782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRTSS

Degron related mutations and impact score

Drug responses associated with ANKS1B mutations

All proteins holding degron of VRTSS