DegronMD - Q7Z6G8(ANKS1B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E580D	TCGA-34-2604	LUSC	TCGA	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0833
p.E580D	DO26433	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0833
p.P511A	TCGA-34-5236	LUSC	TCGA	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.2222
p.P511A	DO26778	LUSC	ICGC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.2222
p.G369R	TCGA-34-7107	LUSC	TCGA	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1389
p.G369R	DO26449	LUSC	ICGC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1389
p.K578T	TCGA-35-5375	LUAD	TCGA	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation substituting flanking lysine	0.25
p.K578T	DO50406	ESAD	ICGC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation substituting flanking lysine	0.25
p.K578T	DO25290	LUAD	ICGC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation substituting flanking lysine	0.25
p.N494K	TCGA-46-6026	LUSC	TCGA	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.3056
p.N494K	TCGA-46-6026	LUSC	TCGA	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1111
p.N494K	DO26740	LUSC	ICGC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.3056
p.N494K	DO26740	LUSC	ICGC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1111
p.G581R	TCGA-49-AARO	LUAD	TCGA	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0556
p.G581R	DO218924	LUAD	ICGC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0556
p.A514P	TCGA-50-5066	LUAD	TCGA	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1389
p.A514P	DO25040	LUAD	ICGC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1389
p.S498R	TCGA-67-3770	LUAD	TCGA	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.1944
p.S498R	TCGA-67-3770	LUAD	TCGA	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.2222
p.S498R	DO23932	LUAD	ICGC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.1944
p.S498R	DO23932	LUAD	ICGC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.2222
p.S770Y	TCGA-85-8070	LUSC	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.1667
p.S770Y	DO26581	LUSC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.1667
p.D505Y	TCGA-94-A5I6	LUSC	TCGA	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation altering degron motif	0.6214
p.D505Y	DO219176	LUSC	ICGC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation altering degron motif	0.6214
p.G491A	TCGA-96-7544	LUSC	TCGA	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation altering degron motif	0.6429
p.G491A	DO26425	LUSC	ICGC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation altering degron motif	0.6429
p.T777A	TCGA-AA-A01P	COAD	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.6028
p.T777A	DO8642	COAD	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.6028
p.D791Y	TCGA-AP-A059	UCEC	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.1111
p.D791Y	TCGA-BR-8487	STAD	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.1111
p.D791Y	DO47867	STAD	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.1111
p.D791Y	DO41361	UCEC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.1111
p.S778L	TCGA-AP-A0LM	UCEC	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.6556
p.S778L	DO51506	PACA	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.6556
p.S778L	DO43306	UCEC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.6556
p.Q374H	TCGA-AP-A1DV	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.2778
p.Q374H	DO43186	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.2778
p.E576K	TCGA-CA-6717	COAD	TCGA	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.1944
p.E576K	DO8264	COAD	ICGC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.1944
p.R496K	TCGA-EB-A551	SKCM	TCGA	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.25
p.R496K	TCGA-EB-A551	SKCM	TCGA	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1667
p.R496K	DO47453	SKCM	ICGC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.25
p.R496K	DO47453	SKCM	ICGC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1667
p.E367K	TCGA-EE-A29D	SKCM	TCGA	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.E367K	DO38123	SKCM	ICGC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.K578R	TCGA-EI-6882	READ	TCGA	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation substituting flanking lysine	0.25
p.K578R	DO36531	READ	ICGC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation substituting flanking lysine	0.25
p.E779Q	TCGA-EY-A1GS	UCEC	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.5633
p.E779Q	DO43162	UCEC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.5633
p.R377I	TCGA-F5-6814	READ	TCGA	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.6991
p.R377I	DO36556	READ	ICGC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.6991
p.K785N	TCGA-F5-6814	READ	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.2778
p.K785N	DO36556	READ	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.2778
p.S778W	TCGA-FD-A6TC	BLCA	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.6763
p.S778W	DO49755	BLCA	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.6763
p.I382V	TCGA-FI-A2F4	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.2778
p.I382V	DO43434	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.2778
p.E366K	TCGA-FR-A726	SKCM	TCGA	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0556
p.E366K	DO48665	SKCM	ICGC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0556
p.V487G	TCGA-HU-A4GH	STAD	TCGA	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation altering degron motif	0.7532
p.V487G	DO47743	STAD	ICGC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation altering degron motif	0.7532
p.D505G	TCGA-HU-A4H3	STAD	TCGA	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation altering degron motif	0.6087
p.D505G	DO47903	STAD	ICGC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation altering degron motif	0.6087
p.T500I	TCGA-P4-AAVL	KIRP	TCGA	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.1389
p.T500I	TCGA-P4-AAVL	KIRP	TCGA	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.2778
p.T500I	DO219694	KIRP	ICGC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.1389
p.T500I	DO219694	KIRP	ICGC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.2778
p.E366D	TCGA-PG-A915	UCEC	TCGA	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0556
p.E366D	DO52422	UCEC	ICGC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0556
p.I783T	TCGA-RC-A7SK	LIHC	TCGA	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.7078
p.I783T	DO52314	LIHC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.7078
p.A514T	TCGA-XK-AAIW	PRAD	TCGA	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1389
p.A514T	DO51407	PRAD	ICGC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1389
p.A514T	SIDM02021	Esophageal Carcinoma	GDSC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1389
p.A561D	DO225072	BRCA	ICGC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.1667
p.A561D	DO227701	BRCA	ICGC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.1667
p.K578M	DO234196	ESAD	ICGC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation substituting flanking lysine	0.25
p.K370E	DO223109	ESCA	ICGC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation substituting flanking lysine	0.2778
p.K370E	DO233199	GACA	ICGC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation substituting flanking lysine	0.2778
p.L368R	DO228676	GACA	ICGC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1111
p.S483T	DO231992	LICA	ICGC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.2222
p.E771K	DO231022	LUSC	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.1944
p.E580V	DO231179	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0833
p.E580V	SIDM00927	Small Cell Lung Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0833
p.E580V	ACH-000871	Lung Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0833
p.E580V	NCI-H510A	lung	COSMIC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0833
p.T773A	DO220881	MELA	ICGC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.25
p.T503A	DO222542	MELA	ICGC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation altering degron motif	0.7139
p.G372R	DO222653	MELA	ICGC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.2222
p.S558G	DO35442	PACA	ICGC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0833
p.V389A	SIDM00588	Oral Cavity Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00373	Endometrial Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00330	Neuroblastoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00496	Thyroid Gland Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00157	Neuroblastoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00553	Acute Myeloid Leukemia	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00002	Neuroblastoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00571	Pancreatic Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00466	Ovarian Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00619	Thyroid Gland Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00351	Oral Cavity Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM01045	Endometrial Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00585	Hepatocellular Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM01180	Hepatocellular Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00498	Colorectal Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM01146	Gastric Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00576	Acute Myeloid Leukemia	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00397	Acute Myeloid Leukemia	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00655	Other Solid Cancers	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00271	Gastric Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00368	Small Cell Lung Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00560	Gastric Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00575	Glioma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00168	Head and Neck Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM01470	Acute Myeloid Leukemia	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM01770	Gastric Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM01368	Gastric Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM00008	Ovarian Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM01347	Ovarian Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM01690	Plasma Cell Myeloma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM01658	Unknown	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM01685	B-Lymphoblastic Leukemia	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM01473	Plasma Cell Myeloma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V389A	SIDM01391	Neuroblastoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.V572L	SIDM00422	Hodgkin's Lymphoma	GDSC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.3056
p.V572L	ACH-001203	Lymphoma	CCLE	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.3056
p.V572L	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.3056
p.P502T	SIDM01117	Small Cell Lung Carcinoma	GDSC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation altering degron motif	0.7031
p.P502T	ACH-002176	Lung Cancer	CCLE	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation altering degron motif	0.7031
p.P502T	NCI-H748	lung	COSMIC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation altering degron motif	0.7031
p.V792A	SIDM00855	Other Sarcomas	GDSC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.0833
p.G581E	SIDM00007	Other Solid Cancers	GDSC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0556
p.G581E	ACH-001550	Skin Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0556
p.G581E	ACH-002396	Bone Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0556
p.G581E	Sarc9371	bone	COSMIC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0556
p.G581E	MCC13	skin	COSMIC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0556
p.K482N	SIDM00255	Neuroblastoma	GDSC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.1944
p.K482N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.1944
p.K482N	NB17	autonomic ganglia	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.1944
p.K482N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.1944
p.P490A	SIDM00231	Kidney Carcinoma	GDSC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation altering degron motif	0.7503
p.P490A	ACH-002167	Kidney Cancer	CCLE	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation altering degron motif	0.7503
p.P490A	NCC010	kidney	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation altering degron motif	0.7503
p.D477Y	SIDM00660	Colorectal Carcinoma	GDSC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.0556
p.D477Y	LS-411N	large intestine	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.0556
p.R499S	SIDM00487	Colorectal Carcinoma	GDSC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.1667
p.R499S	SIDM00487	Colorectal Carcinoma	GDSC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.25
p.R499S	CCK-81	large intestine	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.1667
p.R499S	CCK-81	large intestine	COSMIC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.25
p.E782D	SIDM00487	Colorectal Carcinoma	GDSC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.5647
p.E782D	CCK-81	large intestine	COSMIC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.5647
p.S566T	SIDM00251	Gastric Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.3056
p.S566T	ACH-000949	Gastric Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.3056
p.S566T	TGBC11TKB	stomach	COSMIC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.3056
p.L368F	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1111
p.L368F	ACH-000917	Esophageal Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1111
p.L368F	TE-4	oesophagus	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1111
p.M787I	SIDM00794	Other Solid Cancers	GDSC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.2222
p.M787I	ACH-001442	Skin Cancer	CCLE	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.2222
p.M787I	A388	skin	COSMIC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.2222
p.I790M	SIDM00438	B-Lymphoblastic Leukemia	GDSC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.1389
p.I790M	ACH-002275	Leukemia	CCLE	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.1389
p.I790M	MN-60	haematopoietic and lymphoid tissue	COSMIC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.1389
p.E496K	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.25
p.E496K	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1667
p.E496K	NCI-H2342	lung	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.25
p.E496K	NCI-H2342	lung	COSMIC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1667
p.W780C	SIDM00217	Colorectal Carcinoma	GDSC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.7
p.W780C	SNU-1040	large intestine	COSMIC	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.7
p.D480G	SIDM00720	Mesothelioma	GDSC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.1389
p.D480G	NCI-H28	pleura	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation rewiring degron network	0.1389
p.T777I	ACH-000901	Lung Cancer	CCLE	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation altering degron motif	0.5966
p.D784G	ACH-001991	Primary	CCLE	FTSEWEEI	DEG_MDM2_SWIB_1	776:783	Mutation rewiring degron network	0.3056
p.K366N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0556
p.K366N	NB17	autonomic ganglia	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0556
p.A375T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.3056
p.E380K	NCI-H2342	lung	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7022
p.G383R	MZ7-mel	skin	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.25
p.S370T	C-4-I	cervix	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation substituting flanking lysine	0.2778
p.M367I	A388	skin	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.0833
p.I506V	BICR78	upper aerodigestive tract	COSMIC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation altering degron motif	0.7076
p.A379S	H513	pleura	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7588
p.S488L	SW982	soft tissue	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	487:493	Mutation altering degron motif	0.7667
p.K377I	HCC-44	lung	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7531
p.H387Y	LNCaP-Clone-FGC	prostate	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.1389
p.I572M	NCI-H2110	lung	COSMIC	PPTSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.3056
p.R514H	NCI-H64	lung	COSMIC	PTPDCS	DEG_SCF_FBW7_1	502:507	Mutation rewiring degron network	0.1389
p.E377K	NCI-H2452	pleura	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7022
p.E377K	SNU-61	large intestine	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7022
p.R381C	HT-115	large intestine	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.3056
p.R383S	CCK-81	large intestine	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation rewiring degron network	0.25
p.I370M	MN-60	haematopoietic and lymphoid tissue	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation substituting flanking lysine	0.2778
p.Q377H	C-4-I	cervix	COSMIC	VRTSS	DEG_SPOP_SBC_1	376:380	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKS1B

UniProt ID: Q7Z6G8

Entrez ID: 56899

Protein name: Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKS1B in