DegronMD

Uniprot ID: Q7Z6G8

Source protein: Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Source gene: ANKS1B

Class: DEG_SCF_FBW7_1

Location: 487:493

E3 ligase: FBXW7

DEGRON score: 0.8885

ASA_SCORE: 62.2286

COIL: 0.7953

CONS_SCORE: 0.3389

DSS_SCORE: 0.6952

HELIX: 0.0307

FCONS_SCORE: 0.949

RIG_SCORE: 0.5889

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N494K	TCGA-46-6026	LUSC	TCGA	VTTPGTS	DEG_SCF_FBW7_1	0.3056
p.N494K	DO26740	LUSC	ICGC	VTTPGTS	DEG_SCF_FBW7_1	0.3056
p.S498R	TCGA-67-3770	LUAD	TCGA	VTTPGTS	DEG_SCF_FBW7_1	0.1944
p.S498R	DO23932	LUAD	ICGC	VTTPGTS	DEG_SCF_FBW7_1	0.1944
p.G491A	TCGA-96-7544	LUSC	TCGA	VTTPGTS	DEG_SCF_FBW7_1	0.6429
p.G491A	DO26425	LUSC	ICGC	VTTPGTS	DEG_SCF_FBW7_1	0.6429
p.R496K	TCGA-EB-A551	SKCM	TCGA	VTTPGTS	DEG_SCF_FBW7_1	0.25
p.R496K	DO47453	SKCM	ICGC	VTTPGTS	DEG_SCF_FBW7_1	0.25
p.V487G	TCGA-HU-A4GH	STAD	TCGA	VTTPGTS	DEG_SCF_FBW7_1	0.7532
p.V487G	DO47743	STAD	ICGC	VTTPGTS	DEG_SCF_FBW7_1	0.7532
p.T500I	TCGA-P4-AAVL	KIRP	TCGA	VTTPGTS	DEG_SCF_FBW7_1	0.1389
p.T500I	DO219694	KIRP	ICGC	VTTPGTS	DEG_SCF_FBW7_1	0.1389
p.S483T	DO231992	LICA	ICGC	VTTPGTS	DEG_SCF_FBW7_1	0.2222
p.K482N	SIDM00255	Neuroblastoma	GDSC	VTTPGTS	DEG_SCF_FBW7_1	0.1944
p.K482N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VTTPGTS	DEG_SCF_FBW7_1	0.1944
p.K482N	NB17	autonomic_ganglia	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	0.1944
p.K482N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	0.1944
p.P490A	SIDM00231	Kidney Carcinoma	GDSC	VTTPGTS	DEG_SCF_FBW7_1	0.7503
p.P490A	ACH-002167	Kidney Cancer	CCLE	VTTPGTS	DEG_SCF_FBW7_1	0.7503
p.P490A	NCC010	kidney	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	0.7503
p.D477Y	SIDM00660	Colorectal Carcinoma	GDSC	VTTPGTS	DEG_SCF_FBW7_1	0.0556
p.D477Y	LS-411N	large_intestine	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	0.0556
p.R499S	SIDM00487	Colorectal Carcinoma	GDSC	VTTPGTS	DEG_SCF_FBW7_1	0.1667
p.R499S	CCK-81	large_intestine	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	0.1667
p.E496K	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	VTTPGTS	DEG_SCF_FBW7_1	0.25
p.E496K	NCI-H2342	lung	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	0.25
p.D480G	SIDM00720	Mesothelioma	GDSC	VTTPGTS	DEG_SCF_FBW7_1	0.1389
p.D480G	NCI-H28	pleura	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	0.1389
p.S488L	SW982	soft_tissue	COSMIC	VTTPGTS	DEG_SCF_FBW7_1	0.7667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTTPGTS

Degron related mutations and impact score

Drug responses associated with ANKS1B mutations

All proteins holding degron of VTTPGTS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SCF_FBW7_1	487:493	VTTPGTS	FBXW7	0.8885	More...