DegronMD

Uniprot ID: Q7Z6G8

Source protein: Ankyrin repeat and sterile alpha motif domain-containing protein 1B

Source gene: ANKS1B

Class: DEG_SPOP_SBC_1

Location: 567:571

E3 ligase: SPOP

DEGRON score: 0.9694

ASA_SCORE: 74.58

COIL: 0.9366

CONS_SCORE: 0.3481

DSS_SCORE: 0.6946

HELIX: 0.0268

FCONS_SCORE: 1.0142

RIG_SCORE: 0.5582

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E580D	TCGA-34-2604	LUSC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.0833
p.E580D	DO26433	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.0833
p.K578T	TCGA-35-5375	LUAD	TCGA	PPTSS	DEG_SPOP_SBC_1	0.25
p.K578T	DO50406	ESAD	ICGC	PPTSS	DEG_SPOP_SBC_1	0.25
p.K578T	DO25290	LUAD	ICGC	PPTSS	DEG_SPOP_SBC_1	0.25
p.G581R	TCGA-49-AARO	LUAD	TCGA	PPTSS	DEG_SPOP_SBC_1	0.0556
p.G581R	DO218924	LUAD	ICGC	PPTSS	DEG_SPOP_SBC_1	0.0556
p.E576K	TCGA-CA-6717	COAD	TCGA	PPTSS	DEG_SPOP_SBC_1	0.1944
p.E576K	DO8264	COAD	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1944
p.K578R	TCGA-EI-6882	READ	TCGA	PPTSS	DEG_SPOP_SBC_1	0.25
p.K578R	DO36531	READ	ICGC	PPTSS	DEG_SPOP_SBC_1	0.25
p.A561D	DO225072	BRCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1667
p.A561D	DO227701	BRCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1667
p.K578M	DO234196	ESAD	ICGC	PPTSS	DEG_SPOP_SBC_1	0.25
p.E580V	DO231179	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.0833
p.E580V	SIDM00927	Small Cell Lung Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.0833
p.E580V	ACH-000871	Lung Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	0.0833
p.E580V	NCI-H510A	lung	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.0833
p.S558G	DO35442	PACA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.0833
p.V572L	SIDM00422	Hodgkin's Lymphoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.3056
p.V572L	ACH-001203	Lymphoma	CCLE	PPTSS	DEG_SPOP_SBC_1	0.3056
p.V572L	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.3056
p.G581E	SIDM00007	Other Solid Cancers	GDSC	PPTSS	DEG_SPOP_SBC_1	0.0556
p.G581E	ACH-001550	Skin Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	0.0556
p.G581E	ACH-002396	Bone Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	0.0556
p.G581E	Sarc9371	bone	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.0556
p.G581E	MCC13	skin	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.0556
p.S566T	SIDM00251	Gastric Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.3056
p.S566T	ACH-000949	Gastric Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	0.3056
p.S566T	TGBC11TKB	stomach	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.3056
p.I572M	NCI-H2110	lung	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14773	Tripeptidyl-peptidase 1	DEG_SPOP_SBC_1	177:181	PPTSS	SPOP	0.9584	More...
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	340:344	PPTSS	SPOP	0.6236	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	819:823	PPTSS	SPOP	0.9708	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	176:180	PPTSS	SPOP	0.6895	More...
P52333	Tyrosine-protein kinase JAK3	DEG_SPOP_SBC_1	494:498	PPTSS	SPOP	0.8529	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3890:3894	PPTSS	SPOP	0.5277	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	368:372	PPTSS	SPOP	0.8864	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1119:1123	PPTSS	SPOP	0.925	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1496:1500	PPTSS	SPOP	0.9496	More...
Q15311	RalA-binding protein 1	DEG_SPOP_SBC_1	7:11	PPTSS	SPOP	0.9992	More...
Q7Z2Z1	Treslin	DEG_SPOP_SBC_1	1228:1232	PPTSS	SPOP	0.9477	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	567:571	PPTSS	SPOP	0.9694	More...
Q8TCX5	Rhophilin-1	DEG_SPOP_SBC_1	384:388	PPTSS	SPOP	0.7809	More...
Q93074	Mediator of RNA polymerase II transcription subunit 12	DEG_SPOP_SBC_1	336:340	PPTSS	SPOP	0.7185	More...
Q9H1J1	Regulator of nonsense transcripts 3A	DEG_SPOP_SBC_1	45:49	PPTSS	SPOP	0.9468	More...
Q9H2S1	Small conductance calcium-activated potassium channel protein 2	DEG_SPOP_SBC_1	572:576	PPTSS	SPOP	0.9415	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	512:516	PPTSS	SPOP	0.8871	More...
Q9HCI5	Melanoma-associated antigen E1	DEG_SPOP_SBC_1	141:145	PPTSS	SPOP	0.9976	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	1600:1604	PPTSS	SPOP	0.9908	More...
Q9NT68	Teneurin-2	DEG_SPOP_SBC_1	172:176	PPTSS	SPOP	0.9859	More...
Q6P499	NIPA-like protein 3	DEG_SPOP_SBC_1	15:19	PPTSS	SPOP	0.8666	More...
Q8N801	Protein STPG4	DEG_SPOP_SBC_1	187:191	PPTSS	SPOP	0.5486	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	705:709	PPTSS	SPOP	0.8542	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	727:731	PPTSS	SPOP	0.971	More...
Q9Y4E6	WD repeat-containing protein 7	DEG_SPOP_SBC_1	936:940	PPTSS	SPOP	0.9515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTSS

Degron related mutations and impact score

Drug responses associated with ANKS1B mutations

All proteins holding degron of PPTSS