DegronMD - Q9HBB8(CDHR5)

FUNCTION: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. {ECO:0000269|PubMed:24725409}.

GO - Biological processes (BP): cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intermicrovillar adhesion [GO:0090675]; regulation of microvillus length [GO:0032532]

GO - Molecular function (MF): beta-catenin binding [GO:0008013]; calcium ion binding [GO:0005509]; cell adhesion molecule binding [GO:0050839]

GO - Cellular component (CC): apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; clathrin-coated pit [GO:0005905]; extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; microvillus membrane [GO:0031528]; spanning component of plasma membrane [GO:0044214]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PWTST	DEG_SPOP_SBC_1	SPOP	Cadherin-related family member 5	473:477	More..
PSTTS	DEG_SPOP_SBC_1	SPOP	Cadherin-related family member 5	491:495	More..
PPTSS	DEG_SPOP_SBC_1	SPOP	Cadherin-related family member 5	512:516	More..
VGTST	DEG_SPOP_SBC_1	SPOP	Cadherin-related family member 5	555:559	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S515W	SIDM00612	Glioma	GDSC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7874
p.S515W	KINGS-1	central nervous system	COSMIC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7874
p.P555H	DO229257	THCA	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.7694
p.S515L	SIDM01293	Colorectal Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7667
p.T493M	DO222607	ESCA	ICGC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.7423
p.T493M	SIDM01613	Colorectal Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.7423
p.A493T	DO222769	COCA	ICGC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.7139
p.T475A	SIDM00216	Colorectal Carcinoma	GDSC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation altering degron motif	0.7139
p.T475A	ACH-000989	Colon/Colorectal Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	473:477	Mutation altering degron motif	0.7139
p.V494I	DO233281	GACA	ICGC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.7076
p.V494I	5637	urinary tract	COSMIC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.7076
p.P512T	DO230530	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7031
p.L492F	DO52478	COCA	ICGC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.6981
p.P491A	TCGA-HU-A4H8	STAD	TCGA	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.6392
p.P491A	DO47869	STAD	ICGC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.6392
p.G556E	TCGA-FS-A1ZZ	SKCM	TCGA	VGTST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.6087
p.G556E	DO37412	SKCM	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.6087
p.T557S	SIDM00357	Small Cell Lung Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.6005
p.T557S	ACH-002193	Lung Cancer	CCLE	VGTST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.6005
p.T557S	RERF-LC-FM	lung	COSMIC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.6005

Showing 1 to 20 of 125 entries

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No resistance data available for this Degron.

Kaplan plot for CDHR5 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDHR5

UniProt ID: Q9HBB8

Entrez ID: 53841

Protein name: Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for CDHR5 in