DegronMD - Q9HBB8(CDHR5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G519W	TCGA-21-1070	LUSC	TCGA	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.25
p.G519W	DO27088	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.25
p.P550L	TCGA-B5-A3FA	UCEC	TCGA	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.1944
p.P550L	DO52402	UCEC	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.1944
p.S506F	TCGA-EK-A3GK	CESC	TCGA	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1667
p.S506F	DO49964	CESC	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1667
p.R483I	TCGA-ER-A2NF	SKCM	TCGA	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1667
p.R483I	TCGA-ER-A2NF	SKCM	TCGA	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1111
p.R483I	DO47451	SKCM	ICGC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1667
p.R483I	DO47451	SKCM	ICGC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1111
p.G556E	TCGA-FS-A1ZZ	SKCM	TCGA	VGTST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.6087
p.G556E	DO37412	SKCM	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.6087
p.P491A	TCGA-HU-A4H8	STAD	TCGA	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.6392
p.P491A	DO47869	STAD	ICGC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.6392
p.P550R	TCGA-KU-A66S	HNSC	TCGA	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.1944
p.P550R	DO44456	HNSC	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.1944
p.Q562H	DO48381	BLCA	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.S464W	DO51900	BLCA	ICGC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.0833
p.D520N	DO222427	BTCA	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.2222
p.H503Y	DO222648	BTCA	ICGC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1111
p.H503Y	DO222648	BTCA	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.0833
p.E465D	DO8618	COAD	ICGC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1111
p.S548A	DO230309	COCA	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.1389
p.A493T	DO222769	COCA	ICGC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.7139
p.L492F	DO52478	COCA	ICGC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.6981
p.C508S	DO229010	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.2222
p.C508S	DO229013	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.2222
p.C508S	DO229016	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.2222
p.C508S	DO229003	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.2222
p.C508S	DO229005	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.2222
p.P521S	DO229010	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1944
p.P521S	DO229013	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1944
p.P521S	DO229016	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1944
p.P521S	DO229003	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1944
p.P521S	DO229005	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1944
p.P521S	DO229353	LAML	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1944
p.T493M	DO222607	ESCA	ICGC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.7423
p.T493M	SIDM01613	Colorectal Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.7423
p.V494I	DO233281	GACA	ICGC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.7076
p.V494I	5637	urinary tract	COSMIC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.7076
p.C508F	DO233843	GACA	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.2222
p.P552L	DO229346	LAML	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	DO230556	LUSC	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM01040	Ovarian Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM01005	Acute Myeloid Leukemia	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM00287	B-Lymphoblastic Leukemia	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM00235	Kidney Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM00383	Gastric Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM00292	Small Cell Lung Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM00252	Biliary Tract Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM01653	Non-Cancerous	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM00574	Glioblastoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM00207	Glioblastoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM00988	Kidney Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM00986	Head and Neck Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM00380	Acute Myeloid Leukemia	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM01033	Bladder Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM00168	Head and Neck Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM01660	Kidney Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM01451	Pancreatic Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.P552L	SIDM00497	Colorectal Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.E552V	DO231610	LINC	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.G520R	DO50822	LIRI	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.2222
p.G501S	DO229177	LMS	ICGC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1667
p.P512T	DO230530	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7031
p.G554S	DO230545	LUSC	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.3056
p.S567G	DO230545	LUSC	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.1111
p.G520E	DO220906	MELA	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.2222
p.G497R	DO218859	SKCA	ICGC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.2778
p.V480G	DO229510	SKCA	ICGC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.25
p.G479E	DO37667	SKCM	ICGC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.2778
p.G479R	DO37667	SKCM	ICGC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.2778
p.G479R	HuO-3N1	bone	COSMIC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.2778
p.G479R	MKN1	stomach	COSMIC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.2778
p.E465K	DO37831	SKCM	ICGC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1111
p.P548L	DO38404	STAD	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.1389
p.Q522H	DO229167	THCA	ICGC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1667
p.S548P	DO229253	THCA	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.1389
p.A551T	DO229253	THCA	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.2222
p.P555H	DO229257	THCA	ICGC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.7694
p.A483V	DO43041	UCEC	ICGC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1667
p.A483V	DO43041	UCEC	ICGC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1111
p.A483V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1667
p.A483V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1111
p.S515L	SIDM01293	Colorectal Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7667
p.T475A	SIDM00216	Colorectal Carcinoma	GDSC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation altering degron motif	0.7139
p.T475A	ACH-000989	Colon/Colorectal Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	473:477	Mutation altering degron motif	0.7139
p.P553L	SIDM00477	Esophageal Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.2778
p.P553L	ACH-000383	Esophageal Cancer	CCLE	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.2778
p.P553L	OE33	oesophagus	COSMIC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.2778
p.G546E	SIDM00856	Other Solid Cancers	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.0833
p.G546E	ACH-000096	Rhabdoid	CCLE	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.0833
p.G546E	G-401	soft tissue	COSMIC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.0833
p.T565I	SIDM00282	Colorectal Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.1667
p.T565I	ACH-000998	Colon/Colorectal Cancer	CCLE	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.1667
p.T565I	CW-2	large intestine	COSMIC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.1667
p.V481I	SIDM00965	Small Cell Lung Carcinoma	GDSC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.2222
p.V481I	SIDM00965	Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0556
p.V481I	ACH-000800	Lung Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.2222
p.V481I	ACH-000800	Lung Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0556
p.V481I	NCI-H446	lung	COSMIC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.2222
p.V481I	NCI-H446	lung	COSMIC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0556
p.S515W	SIDM00612	Glioma	GDSC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7874
p.S515W	KINGS-1	central nervous system	COSMIC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7874
p.T557S	SIDM00357	Small Cell Lung Carcinoma	GDSC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.6005
p.T557S	ACH-002193	Lung Cancer	CCLE	VGTST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.6005
p.T557S	RERF-LC-FM	lung	COSMIC	VGTST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.6005
p.P482L	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1944
p.P482L	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0833
p.P482L	ACH-000904	Lung Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1944
p.P482L	ACH-000904	Lung Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0833
p.P482L	ACH-001362	Lung Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1944
p.P482L	ACH-001362	Lung Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0833
p.P513S	SIDM00068	Colorectal Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.5641
p.G507S	SIDM01617	Endometrial Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1944
p.G507S	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1944
p.P482H	SIDM01617	Endometrial Carcinoma	GDSC	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1944
p.P482H	SIDM01617	Endometrial Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0833
p.P482H	ACH-000994	Endometrial/Uterine Cancer	CCLE	PWTST	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1944
p.P482H	ACH-000994	Endometrial/Uterine Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0833
p.G569D	ACH-000431	Lung Cancer	CCLE	VGTST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.0556
p.G498E	ACH-001521	Skin Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.25
p.L490V	MCC13	skin	COSMIC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.3056
p.L490H	NCI-H747	large intestine	COSMIC	PSTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDHR5

UniProt ID: Q9HBB8

Entrez ID: 53841

Protein name: Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDHR5 in