DegronMD

Uniprot ID: Q9HBB8

Source protein: Cadherin-related family member 5

Source gene: CDHR5

Class: DEG_SPOP_SBC_1

Location: 512:516

E3 ligase: SPOP

DEGRON score: 0.8871

ASA_SCORE: 75.44

COIL: 0.897

CONS_SCORE: 0.5224

DSS_SCORE: 0.9106

HELIX: 0.0168

FCONS_SCORE: 0.8584

RIG_SCORE: 0.5195

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G519W	TCGA-21-1070	LUSC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.25
p.G519W	DO27088	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.25
p.S506F	TCGA-EK-A3GK	CESC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.1667
p.S506F	DO49964	CESC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1667
p.D520N	DO222427	BTCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.H503Y	DO222648	BTCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.0833
p.C508S	DO229010	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.C508S	DO229013	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.C508S	DO229016	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.C508S	DO229003	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.C508S	DO229005	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.P521S	DO229010	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1944
p.P521S	DO229013	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1944
p.P521S	DO229016	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1944
p.P521S	DO229003	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1944
p.P521S	DO229005	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1944
p.P521S	DO229353	LAML	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1944
p.C508F	DO233843	GACA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.G520R	DO50822	LIRI	ICGC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.P512T	DO230530	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.7031
p.G520E	DO220906	MELA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.Q522H	DO229167	THCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1667
p.S515L	SIDM01293	Colorectal Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.7667
p.S515W	SIDM00612	Glioma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.7874
p.S515W	KINGS-1	central_nervous_system	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.7874
p.P513S	SIDM00068	Colorectal Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.5641
p.G507S	SIDM01617	Endometrial Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.1944
p.G507S	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14773	Tripeptidyl-peptidase 1	DEG_SPOP_SBC_1	177:181	PPTSS	SPOP	0.9584	More...
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	340:344	PPTSS	SPOP	0.6236	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	819:823	PPTSS	SPOP	0.9708	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	176:180	PPTSS	SPOP	0.6895	More...
P52333	Tyrosine-protein kinase JAK3	DEG_SPOP_SBC_1	494:498	PPTSS	SPOP	0.8529	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3890:3894	PPTSS	SPOP	0.5277	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	368:372	PPTSS	SPOP	0.8864	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1119:1123	PPTSS	SPOP	0.925	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1496:1500	PPTSS	SPOP	0.9496	More...
Q15311	RalA-binding protein 1	DEG_SPOP_SBC_1	7:11	PPTSS	SPOP	0.9992	More...
Q7Z2Z1	Treslin	DEG_SPOP_SBC_1	1228:1232	PPTSS	SPOP	0.9477	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	567:571	PPTSS	SPOP	0.9694	More...
Q8TCX5	Rhophilin-1	DEG_SPOP_SBC_1	384:388	PPTSS	SPOP	0.7809	More...
Q93074	Mediator of RNA polymerase II transcription subunit 12	DEG_SPOP_SBC_1	336:340	PPTSS	SPOP	0.7185	More...
Q9H1J1	Regulator of nonsense transcripts 3A	DEG_SPOP_SBC_1	45:49	PPTSS	SPOP	0.9468	More...
Q9H2S1	Small conductance calcium-activated potassium channel protein 2	DEG_SPOP_SBC_1	572:576	PPTSS	SPOP	0.9415	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	512:516	PPTSS	SPOP	0.8871	More...
Q9HCI5	Melanoma-associated antigen E1	DEG_SPOP_SBC_1	141:145	PPTSS	SPOP	0.9976	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	1600:1604	PPTSS	SPOP	0.9908	More...
Q9NT68	Teneurin-2	DEG_SPOP_SBC_1	172:176	PPTSS	SPOP	0.9859	More...
Q6P499	NIPA-like protein 3	DEG_SPOP_SBC_1	15:19	PPTSS	SPOP	0.8666	More...
Q8N801	Protein STPG4	DEG_SPOP_SBC_1	187:191	PPTSS	SPOP	0.5486	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	705:709	PPTSS	SPOP	0.8542	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	727:731	PPTSS	SPOP	0.971	More...
Q9Y4E6	WD repeat-containing protein 7	DEG_SPOP_SBC_1	936:940	PPTSS	SPOP	0.9515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTSS

Degron related mutations and impact score

Drug responses associated with CDHR5 mutations

All proteins holding degron of PPTSS