DegronMD

Uniprot ID: Q9HCJ0

Source protein: Trinucleotide repeat-containing gene 6C protein

Source gene: TNRC6C

Class: DEG_SPOP_SBC_1

Location: 1600:1604

E3 ligase: SPOP

DEGRON score: 0.9908

ASA_SCORE: 79.7

COIL: 0.9198

CONS_SCORE: 0.4671

DSS_SCORE: 0.5174

HELIX: 0.0574

FCONS_SCORE: 1.0786

RIG_SCORE: 0.6617

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1599V	TCGA-BR-4362	STAD	TCGA	PPTSS	DEG_SPOP_SBC_1	0.3056
p.A1599V	DO38336	STAD	ICGC	PPTSS	DEG_SPOP_SBC_1	0.3056
p.N1612S	TCGA-E6-A1LX	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.1111
p.N1612S	DO41020	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1111
p.Q1602K	TCGA-FS-A1ZP	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	0.6944
p.Q1602K	DO37703	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	0.6944
p.R1591L	DO229034	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.0833
p.V1590I	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PPTSS	DEG_SPOP_SBC_1	0.0556
p.V1590I	ACH-000920	Leukemia	CCLE	PPTSS	DEG_SPOP_SBC_1	0.0556
p.V1590I	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.0556
p.S1594F	SIDM01175	Other Sarcomas	GDSC	PPTSS	DEG_SPOP_SBC_1	0.1667
p.S1594F	ACH-002309	Sarcoma	CCLE	PPTSS	DEG_SPOP_SBC_1	0.1667
p.S1594F	SW684	soft_tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.1667
p.P1600T	ACH-000756	Brain Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	0.7031
p.P1600T	GI-1	central_nervous_system	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.7031
p.N1599S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14773	Tripeptidyl-peptidase 1	DEG_SPOP_SBC_1	177:181	PPTSS	SPOP	0.9584	More...
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	340:344	PPTSS	SPOP	0.6236	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	819:823	PPTSS	SPOP	0.9708	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	176:180	PPTSS	SPOP	0.6895	More...
P52333	Tyrosine-protein kinase JAK3	DEG_SPOP_SBC_1	494:498	PPTSS	SPOP	0.8529	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3890:3894	PPTSS	SPOP	0.5277	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	368:372	PPTSS	SPOP	0.8864	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1119:1123	PPTSS	SPOP	0.925	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1496:1500	PPTSS	SPOP	0.9496	More...
Q15311	RalA-binding protein 1	DEG_SPOP_SBC_1	7:11	PPTSS	SPOP	0.9992	More...
Q7Z2Z1	Treslin	DEG_SPOP_SBC_1	1228:1232	PPTSS	SPOP	0.9477	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	567:571	PPTSS	SPOP	0.9694	More...
Q8TCX5	Rhophilin-1	DEG_SPOP_SBC_1	384:388	PPTSS	SPOP	0.7809	More...
Q93074	Mediator of RNA polymerase II transcription subunit 12	DEG_SPOP_SBC_1	336:340	PPTSS	SPOP	0.7185	More...
Q9H1J1	Regulator of nonsense transcripts 3A	DEG_SPOP_SBC_1	45:49	PPTSS	SPOP	0.9468	More...
Q9H2S1	Small conductance calcium-activated potassium channel protein 2	DEG_SPOP_SBC_1	572:576	PPTSS	SPOP	0.9415	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	512:516	PPTSS	SPOP	0.8871	More...
Q9HCI5	Melanoma-associated antigen E1	DEG_SPOP_SBC_1	141:145	PPTSS	SPOP	0.9976	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	1600:1604	PPTSS	SPOP	0.9908	More...
Q9NT68	Teneurin-2	DEG_SPOP_SBC_1	172:176	PPTSS	SPOP	0.9859	More...
Q6P499	NIPA-like protein 3	DEG_SPOP_SBC_1	15:19	PPTSS	SPOP	0.8666	More...
Q8N801	Protein STPG4	DEG_SPOP_SBC_1	187:191	PPTSS	SPOP	0.5486	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	705:709	PPTSS	SPOP	0.8542	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	727:731	PPTSS	SPOP	0.971	More...
Q9Y4E6	WD repeat-containing protein 7	DEG_SPOP_SBC_1	936:940	PPTSS	SPOP	0.9515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTSS

Degron related mutations and impact score

Drug responses associated with TNRC6C mutations

All proteins holding degron of PPTSS