DegronMD

Uniprot ID: O60641

Source protein: Clathrin coat assembly protein AP180

Source gene: SNAP91

Class: DEG_SPOP_SBC_1

Location: 819:823

E3 ligase: SPOP

DEGRON score: 0.9708

ASA_SCORE: 84.66

COIL: 0.9602

CONS_SCORE: 0.2488

DSS_SCORE: 0.5318

HELIX: 0.0112

FCONS_SCORE: 0.8661

RIG_SCORE: 0.6086

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A812V	TCGA-06-2561	GBM	TCGA	PPTSS	DEG_SPOP_SBC_1	0.1389
p.S832P	TCGA-2W-A8YY	CESC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.0833
p.S811I	TCGA-D1-A103	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.1111
p.V833I	TCGA-EE-A2GC	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	0.0556
p.P825S	TCGA-EE-A3JI	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	0.2778
p.P825S	TCGA-FW-A3R5	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	0.2778
p.P820S	TCGA-FR-A729	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	0.5641
p.P820S	TCGA-RP-A694	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	0.5641
p.P809S	TCGA-R6-A6DN	ESCA	TCGA	PPTSS	DEG_SPOP_SBC_1	0.0556
p.V824L	TCGA-RC-A6M3	LIHC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.3056
p.V827I	DO219573	LIHC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.A815S	DO23342	LINC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.P814H	DO45299	LIRI	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1944
p.P814H	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.1944
p.G816E	DO223718	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.25
p.G816E	DO37483	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	0.25
p.G816E	COLO-792	skin	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.25
p.G811E	DO222775	MELA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1111
p.G811E	DO47665	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1111
p.P813H	DO46368	OV	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1667
p.M833I	DO50292	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	0.0556
p.F829L	DO47337	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1667
p.G811R	DO41911	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1111
p.G829R	SIDM01278	Colorectal Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.1667
p.P831Q	SIDM01387	Small Cell Lung Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.1111
p.P831Q	ACH-000921	Lung Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14773	Tripeptidyl-peptidase 1	DEG_SPOP_SBC_1	177:181	PPTSS	SPOP	0.9584	More...
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	340:344	PPTSS	SPOP	0.6236	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	819:823	PPTSS	SPOP	0.9708	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	176:180	PPTSS	SPOP	0.6895	More...
P52333	Tyrosine-protein kinase JAK3	DEG_SPOP_SBC_1	494:498	PPTSS	SPOP	0.8529	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3890:3894	PPTSS	SPOP	0.5277	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	368:372	PPTSS	SPOP	0.8864	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1119:1123	PPTSS	SPOP	0.925	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1496:1500	PPTSS	SPOP	0.9496	More...
Q15311	RalA-binding protein 1	DEG_SPOP_SBC_1	7:11	PPTSS	SPOP	0.9992	More...
Q7Z2Z1	Treslin	DEG_SPOP_SBC_1	1228:1232	PPTSS	SPOP	0.9477	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	567:571	PPTSS	SPOP	0.9694	More...
Q8TCX5	Rhophilin-1	DEG_SPOP_SBC_1	384:388	PPTSS	SPOP	0.7809	More...
Q93074	Mediator of RNA polymerase II transcription subunit 12	DEG_SPOP_SBC_1	336:340	PPTSS	SPOP	0.7185	More...
Q9H1J1	Regulator of nonsense transcripts 3A	DEG_SPOP_SBC_1	45:49	PPTSS	SPOP	0.9468	More...
Q9H2S1	Small conductance calcium-activated potassium channel protein 2	DEG_SPOP_SBC_1	572:576	PPTSS	SPOP	0.9415	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	512:516	PPTSS	SPOP	0.8871	More...
Q9HCI5	Melanoma-associated antigen E1	DEG_SPOP_SBC_1	141:145	PPTSS	SPOP	0.9976	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	1600:1604	PPTSS	SPOP	0.9908	More...
Q9NT68	Teneurin-2	DEG_SPOP_SBC_1	172:176	PPTSS	SPOP	0.9859	More...
Q6P499	NIPA-like protein 3	DEG_SPOP_SBC_1	15:19	PPTSS	SPOP	0.8666	More...
Q8N801	Protein STPG4	DEG_SPOP_SBC_1	187:191	PPTSS	SPOP	0.5486	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	705:709	PPTSS	SPOP	0.8542	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	727:731	PPTSS	SPOP	0.971	More...
Q9Y4E6	WD repeat-containing protein 7	DEG_SPOP_SBC_1	936:940	PPTSS	SPOP	0.9515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTSS

Degron related mutations and impact score

Drug responses associated with SNAP91 mutations

All proteins holding degron of PPTSS