DegronMD

Uniprot ID: O14773

Source protein: Tripeptidyl-peptidase 1

Source gene: TPP1

Class: DEG_SPOP_SBC_1

Location: 177:181

E3 ligase: SPOP

DEGRON score: 0.9584

ASA_SCORE: 66.52

COIL: 0.9068

CONS_SCORE: 0.4006

DSS_SCORE: 0.5817

HELIX: 0.075

FCONS_SCORE: 0.9333

RIG_SCORE: 0.6782

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R185H	TCGA-29-1785	OV	TCGA	PPTSS	DEG_SPOP_SBC_1	0.2222
p.R185H	TCGA-AX-A1CE	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.2222
p.R185H	DO31624	OV	ICGC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.R185H	DO42280	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.V170M	TCGA-A2-A0EM	BRCA	TCGA	PPTSS	DEG_SPOP_SBC_1	0.1389
p.S177L	DO45318	LUAD	ICGC	PPTSS	DEG_SPOP_SBC_1	0.7667
p.P191H	DO51774	STAD	ICGC	PPTSS	DEG_SPOP_SBC_1	0.0556
p.S170N	DO42312	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1389
p.P191T	DO42825	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.0556
p.L182Q	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PPTSS	DEG_SPOP_SBC_1	0.3056
p.L182Q	ACH-000795	Leukemia	CCLE	PPTSS	DEG_SPOP_SBC_1	0.3056
p.L182Q	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.3056
p.R185C	SIDM00969	Ovarian Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.R185C	SIDM00032	Bladder Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.R185C	SIDM00793	Burkitt's Lymphoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.S181F	SIDM00656	Burkitt's Lymphoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.7982
p.S181F	SIDM00808	Burkitt's Lymphoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.7982
p.S181F	SIDM00641	Burkitt's Lymphoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.7982
p.S181F	SIDM01254	Burkitt's Lymphoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.7982
p.R175P	RCC-AB	kidney	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.2778
p.R175P	OACp4C	oesophagus	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.2778
p.R173W	42-MG-BA	central_nervous_system	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.2222
p.R173Q	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14773	Tripeptidyl-peptidase 1	DEG_SPOP_SBC_1	177:181	PPTSS	SPOP	0.9584	More...
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	340:344	PPTSS	SPOP	0.6236	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	819:823	PPTSS	SPOP	0.9708	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	176:180	PPTSS	SPOP	0.6895	More...
P52333	Tyrosine-protein kinase JAK3	DEG_SPOP_SBC_1	494:498	PPTSS	SPOP	0.8529	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3890:3894	PPTSS	SPOP	0.5277	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	368:372	PPTSS	SPOP	0.8864	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1119:1123	PPTSS	SPOP	0.925	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1496:1500	PPTSS	SPOP	0.9496	More...
Q15311	RalA-binding protein 1	DEG_SPOP_SBC_1	7:11	PPTSS	SPOP	0.9992	More...
Q7Z2Z1	Treslin	DEG_SPOP_SBC_1	1228:1232	PPTSS	SPOP	0.9477	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	567:571	PPTSS	SPOP	0.9694	More...
Q8TCX5	Rhophilin-1	DEG_SPOP_SBC_1	384:388	PPTSS	SPOP	0.7809	More...
Q93074	Mediator of RNA polymerase II transcription subunit 12	DEG_SPOP_SBC_1	336:340	PPTSS	SPOP	0.7185	More...
Q9H1J1	Regulator of nonsense transcripts 3A	DEG_SPOP_SBC_1	45:49	PPTSS	SPOP	0.9468	More...
Q9H2S1	Small conductance calcium-activated potassium channel protein 2	DEG_SPOP_SBC_1	572:576	PPTSS	SPOP	0.9415	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	512:516	PPTSS	SPOP	0.8871	More...
Q9HCI5	Melanoma-associated antigen E1	DEG_SPOP_SBC_1	141:145	PPTSS	SPOP	0.9976	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	1600:1604	PPTSS	SPOP	0.9908	More...
Q9NT68	Teneurin-2	DEG_SPOP_SBC_1	172:176	PPTSS	SPOP	0.9859	More...
Q6P499	NIPA-like protein 3	DEG_SPOP_SBC_1	15:19	PPTSS	SPOP	0.8666	More...
Q8N801	Protein STPG4	DEG_SPOP_SBC_1	187:191	PPTSS	SPOP	0.5486	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	705:709	PPTSS	SPOP	0.8542	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	727:731	PPTSS	SPOP	0.971	More...
Q9Y4E6	WD repeat-containing protein 7	DEG_SPOP_SBC_1	936:940	PPTSS	SPOP	0.9515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTSS

Degron related mutations and impact score

Drug responses associated with TPP1 mutations

All proteins holding degron of PPTSS