DegronMD - Q9H2S1(KCNN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R563W	TCGA-17-Z045	LUAD	TCGA	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.0833
p.A57S	TCGA-33-4547	LUSC	TCGA	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.3056
p.A57S	DO26546	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.3056
p.S562C	TCGA-77-8133	LUSC	TCGA	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation blocking phosphorylation signal	0.5
p.S562C	DO27039	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation blocking phosphorylation signal	0.5
p.R566W	TCGA-A5-A1OF	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.1667
p.R566W	TCGA-AX-A06F	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.1667
p.R566W	DO41752	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.1667
p.R566W	DO42568	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.1667
p.S562Y	TCGA-A8-A0A7	BRCA	TCGA	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation blocking phosphorylation signal	0.5
p.S562Y	DO5936	BRCA	ICGC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation blocking phosphorylation signal	0.5
p.R565W	TCGA-AX-A05W	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.1389
p.R565W	DO50315	ESAD	ICGC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.1389
p.R565W	DO40966	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.1389
p.S575L	TCGA-BH-A18J	BRCA	TCGA	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation altering degron motif	0.7667
p.S575L	DO4527	BRCA	ICGC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation altering degron motif	0.7667
p.R21S	TCGA-HE-7129	KIRP	TCGA	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation altering degron motif	0.7427
p.R21S	DO20786	KIRP	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation altering degron motif	0.7427
p.V10I	TCGA-HU-A4GT	STAD	TCGA	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.0556
p.V10I	DO48020	STAD	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.0556
p.A38V	TCGA-HU-A4H8	STAD	TCGA	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.0556
p.A38V	DO229480	LAML	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.0556
p.A38V	DO47869	STAD	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.0556
p.S62L	TCGA-MA-AA41	CESC	TCGA	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.7667
p.S62L	DO219723	CESC	ICGC	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.7667
p.E72K	TCGA-R6-A6KZ	ESCA	TCGA	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.S48P	TCGA-S9-A7R8	LGG	TCGA	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.S48P	DO50220	LGG	ICGC	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.S575A	TCGA-UF-A71E	HNSC	TCGA	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation altering degron motif	0.7588
p.S575A	DO52110	HNSC	ICGC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation altering degron motif	0.7588
p.G36C	DO224582	BRCA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.1111
p.G36C	DO1007	BRCA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.1111
p.G31E	DO1187	BRCA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.25
p.R21H	DO229389	BTCA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation altering degron motif	0.8244
p.E55D	DO10443	COAD	ICGC	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.25
p.T65N	DO8264	COAD	ICGC	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.25
p.S578N	DO234326	ESAD	ICGC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.2778
p.S578N	DO46396	OV	ICGC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.2778
p.A19V	DO233156	GACA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.3056
p.Q66R	DO233780	GACA	ICGC	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.2222
p.V67M	DO233903	GACA	ICGC	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.A58S	DO14343	HNSC	ICGC	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.7588
p.G34C	DO20835	KIRP	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.1667
p.G12V	DO229019	LICA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.1111
p.V17L	DO229019	LICA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.25
p.A35S	DO229034	LICA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.1389
p.P13S	DO50970	LICA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.1389
p.L29V	DO52210	LIHC	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.3056
p.P36T	DO45083	LINC	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.1111
p.P572L	DO227579	ORCA	ICGC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation altering degron motif	0.7582
p.V17I	DO50288	SKCM	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.25
p.I11V	DO43250	UCEC	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.0833
p.A19S	SIDM00845	Burkitt's Lymphoma	GDSC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.3056
p.A19S	Daudi	haematopoietic and lymphoid tissue	COSMIC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.3056
p.S60L	SIDM00121	T-Lymphoblastic Leukemia	GDSC	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.7667
p.S60L	ACH-000652	Pancreatic Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.7667
p.S562F	SIDM00882	Breast Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation blocking phosphorylation signal	0.5
p.S562F	ACH-000277	Breast Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation blocking phosphorylation signal	0.5
p.S562F	HCC1419	breast	COSMIC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation blocking phosphorylation signal	0.5
p.P49T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.P49T	ACH-000878	Lung Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.E65Q	SIDM00954	Breast Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.25
p.P33L	SIDM00153	T-Lymphoblastic Leukemia	GDSC	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.1944
p.P33L	ACH-000964	Leukemia	CCLE	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation rewiring degron network	0.1944
p.N23K	ACH-000593	Bladder Cancer	CCLE	SRRNLHEMD	DEG_APCC_DBOX_1	20:28	Mutation altering degron motif	0.5806
p.A55T	ACH-000985	Colon/Colorectal Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.25
p.I66M	ACH-001376	Pancreatic Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.2222
p.E65D	ACH-001804	Liposarcoma	CCLE	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.25
p.K72Q	SK-HEP-1	liver	COSMIC	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.K48R	SW1783	central nervous system	COSMIC	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.V58M	NUGC-3	stomach	COSMIC	AVSSS	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.7208
p.S565F	HCC1419	breast	COSMIC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.1389
p.R562Q	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation blocking phosphorylation signal	0.5
p.S564L	NCI-H1993	lung	COSMIC	PPTSS	DEG_SPOP_SBC_1	572:576	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNN2

UniProt ID: Q9H2S1

Entrez ID: 3781

Protein name: Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNN2 in