DegronMD

Uniprot ID: Q9H2S1

Source protein: Small conductance calcium-activated potassium channel protein 2

Source gene: KCNN2

Class: DEG_APCC_DBOX_1

Location: 20:28

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9885

ASA_SCORE: 97.3111

COIL: 0.6348

CONS_SCORE: 0.3901

DSS_SCORE: 0.6436

HELIX: 0.3352

FCONS_SCORE: 1.0317

RIG_SCORE: 0.6812

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R21S	TCGA-HE-7129	KIRP	TCGA	SRRNLHEMD	DEG_APCC_DBOX_1	0.7427
p.R21S	DO20786	KIRP	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.7427
p.V10I	TCGA-HU-A4GT	STAD	TCGA	SRRNLHEMD	DEG_APCC_DBOX_1	0.0556
p.V10I	DO48020	STAD	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.0556
p.A38V	TCGA-HU-A4H8	STAD	TCGA	SRRNLHEMD	DEG_APCC_DBOX_1	0.0556
p.A38V	DO229480	LAML	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.0556
p.A38V	DO47869	STAD	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.0556
p.G36C	DO224582	BRCA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.1111
p.G36C	DO1007	BRCA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.1111
p.G31E	DO1187	BRCA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.25
p.R21H	DO229389	BTCA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.8244
p.A19V	DO233156	GACA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.3056
p.G34C	DO20835	KIRP	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.1667
p.G12V	DO229019	LICA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.1111
p.V17L	DO229019	LICA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.25
p.A35S	DO229034	LICA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.1389
p.P13S	DO50970	LICA	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.1389
p.L29V	DO52210	LIHC	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.3056
p.P36T	DO45083	LINC	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.1111
p.V17I	DO50288	SKCM	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.25
p.I11V	DO43250	UCEC	ICGC	SRRNLHEMD	DEG_APCC_DBOX_1	0.0833
p.A19S	SIDM00845	Burkitt's Lymphoma	GDSC	SRRNLHEMD	DEG_APCC_DBOX_1	0.3056
p.A19S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	SRRNLHEMD	DEG_APCC_DBOX_1	0.3056
p.P33L	SIDM00153	T-Lymphoblastic Leukemia	GDSC	SRRNLHEMD	DEG_APCC_DBOX_1	0.1944
p.P33L	ACH-000964	Leukemia	CCLE	SRRNLHEMD	DEG_APCC_DBOX_1	0.1944
p.N23K	ACH-000593	Bladder Cancer	CCLE	SRRNLHEMD	DEG_APCC_DBOX_1	0.5806

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2S1	Small conductance calcium-activated potassium channel protein 2	DEG_APCC_DBOX_1	20:28	SRRNLHEMD	APC,CDC20,FZR1	0.9885	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRRNLHEMD

Degron related mutations and impact score

Drug responses associated with KCNN2 mutations

All proteins holding degron of SRRNLHEMD