DegronMD

Uniprot ID: Q9H2S1

Source protein: Small conductance calcium-activated potassium channel protein 2

Source gene: KCNN2

Class: DEG_SPOP_SBC_1

Location: 572:576

E3 ligase: SPOP

DEGRON score: 0.9415

ASA_SCORE: 91.62

COIL: 0.9768

CONS_SCORE: 0.2959

DSS_SCORE: 0.8836

HELIX: 0.0122

FCONS_SCORE: 1.0013

RIG_SCORE: 0.507

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R563W	TCGA-17-Z045	LUAD	TCGA	PPTSS	DEG_SPOP_SBC_1	0.0833
p.S562C	TCGA-77-8133	LUSC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.5
p.S562C	DO27039	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.5
p.R566W	TCGA-A5-A1OF	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.1667
p.R566W	TCGA-AX-A06F	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.1667
p.R566W	DO41752	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1667
p.R566W	DO42568	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1667
p.S562Y	TCGA-A8-A0A7	BRCA	TCGA	PPTSS	DEG_SPOP_SBC_1	0.5
p.S562Y	DO5936	BRCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.5
p.R565W	TCGA-AX-A05W	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.1389
p.R565W	DO50315	ESAD	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1389
p.R565W	DO40966	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.1389
p.S575L	TCGA-BH-A18J	BRCA	TCGA	PPTSS	DEG_SPOP_SBC_1	0.7667
p.S575L	DO4527	BRCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.7667
p.S575A	TCGA-UF-A71E	HNSC	TCGA	PPTSS	DEG_SPOP_SBC_1	0.7588
p.S575A	DO52110	HNSC	ICGC	PPTSS	DEG_SPOP_SBC_1	0.7588
p.S578N	DO234326	ESAD	ICGC	PPTSS	DEG_SPOP_SBC_1	0.2778
p.S578N	DO46396	OV	ICGC	PPTSS	DEG_SPOP_SBC_1	0.2778
p.P572L	DO227579	ORCA	ICGC	PPTSS	DEG_SPOP_SBC_1	0.7582
p.S562F	SIDM00882	Breast Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	0.5
p.S562F	ACH-000277	Breast Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	0.5
p.S562F	HCC1419	breast	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.5
p.S565F	HCC1419	breast	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.1389
p.R562Q	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.5
p.S564L	NCI-H1993	lung	COSMIC	PPTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14773	Tripeptidyl-peptidase 1	DEG_SPOP_SBC_1	177:181	PPTSS	SPOP	0.9584	More...
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	340:344	PPTSS	SPOP	0.6236	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	819:823	PPTSS	SPOP	0.9708	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	176:180	PPTSS	SPOP	0.6895	More...
P52333	Tyrosine-protein kinase JAK3	DEG_SPOP_SBC_1	494:498	PPTSS	SPOP	0.8529	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3890:3894	PPTSS	SPOP	0.5277	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	368:372	PPTSS	SPOP	0.8864	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1119:1123	PPTSS	SPOP	0.925	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1496:1500	PPTSS	SPOP	0.9496	More...
Q15311	RalA-binding protein 1	DEG_SPOP_SBC_1	7:11	PPTSS	SPOP	0.9992	More...
Q7Z2Z1	Treslin	DEG_SPOP_SBC_1	1228:1232	PPTSS	SPOP	0.9477	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	567:571	PPTSS	SPOP	0.9694	More...
Q8TCX5	Rhophilin-1	DEG_SPOP_SBC_1	384:388	PPTSS	SPOP	0.7809	More...
Q93074	Mediator of RNA polymerase II transcription subunit 12	DEG_SPOP_SBC_1	336:340	PPTSS	SPOP	0.7185	More...
Q9H1J1	Regulator of nonsense transcripts 3A	DEG_SPOP_SBC_1	45:49	PPTSS	SPOP	0.9468	More...
Q9H2S1	Small conductance calcium-activated potassium channel protein 2	DEG_SPOP_SBC_1	572:576	PPTSS	SPOP	0.9415	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	512:516	PPTSS	SPOP	0.8871	More...
Q9HCI5	Melanoma-associated antigen E1	DEG_SPOP_SBC_1	141:145	PPTSS	SPOP	0.9976	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	1600:1604	PPTSS	SPOP	0.9908	More...
Q9NT68	Teneurin-2	DEG_SPOP_SBC_1	172:176	PPTSS	SPOP	0.9859	More...
Q6P499	NIPA-like protein 3	DEG_SPOP_SBC_1	15:19	PPTSS	SPOP	0.8666	More...
Q8N801	Protein STPG4	DEG_SPOP_SBC_1	187:191	PPTSS	SPOP	0.5486	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	705:709	PPTSS	SPOP	0.8542	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	727:731	PPTSS	SPOP	0.971	More...
Q9Y4E6	WD repeat-containing protein 7	DEG_SPOP_SBC_1	936:940	PPTSS	SPOP	0.9515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTSS

Degron related mutations and impact score

Drug responses associated with KCNN2 mutations

All proteins holding degron of PPTSS