DegronMD - Q8TCX5(RHPN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W669L	TCGA-49-4487	LUAD	TCGA	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation rewiring degron network	0.0556
p.W669L	DO24780	LUAD	ICGC	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation rewiring degron network	0.0556
p.P660L	TCGA-4X-A9FD	THYM	TCGA	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation rewiring degron network	0.3056
p.P650S	TCGA-D3-A5GO	SKCM	TCGA	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation rewiring degron network	0.3056
p.P650S	DO47419	SKCM	ICGC	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation rewiring degron network	0.3056
p.E378K	TCGA-EI-6917	READ	TCGA	PPTSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1667
p.E378K	DO36881	READ	ICGC	PPTSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1667
p.P655T	TCGA-GN-A262	SKCM	TCGA	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation altering degron motif	0.5919
p.P655T	DO37515	SKCM	ICGC	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation altering degron motif	0.5919
p.P660Q	DO35749	PBCA	ICGC	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation rewiring degron network	0.3056
p.P667S	DO232224	PBCA	ICGC	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation rewiring degron network	0.1111
p.Q651H	DO229248	THCA	ICGC	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation altering degron motif	0.647
p.V656A	DO229242	THCA	ICGC	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation altering degron motif	0.6936
p.P655L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation altering degron motif	0.6471
p.P655L	ACH-000981	Leukemia	CCLE	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation altering degron motif	0.6471
p.P655L	DND-41	haematopoietic and lymphoid tissue	COSMIC	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation altering degron motif	0.6471
p.S663T	SIDM00501	Oral Cavity Carcinoma	GDSC	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation rewiring degron network	0.2222
p.S663T	BICR78	upper aerodigestive tract	COSMIC	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation rewiring degron network	0.2222
p.Q643E	SIDM00210	Ovarian Carcinoma	GDSC	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation rewiring degron network	0.1111
p.Q643E	ACH-000657	Ovarian Cancer	CCLE	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation rewiring degron network	0.1111
p.Q643E	A2780	ovary	COSMIC	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation rewiring degron network	0.1111
p.Q643H	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation rewiring degron network	0.1111
p.Q643H	Calu-6	lung	COSMIC	QPCAPVKPA	DEG_SIAH_1	651:659	Mutation rewiring degron network	0.1111

Kaplan plot for RHPN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RHPN1

UniProt ID: Q8TCX5

Entrez ID: 114822

Protein name: Rhophilin-1 (GTP-Rho-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RHPN1 in