DegronMD

Uniprot ID: Q8TCX5

Source protein: Rhophilin-1

Source gene: RHPN1

Class: DEG_SIAH_1

Location: 651:659

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9786

ASA_SCORE: 86.6111

COIL: 0.9203

CONS_SCORE: 0.2489

DSS_SCORE: 0.6042

HELIX: 0.0208

FCONS_SCORE: 0.8903

RIG_SCORE: 0.6434

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W669L	TCGA-49-4487	LUAD	TCGA	QPCAPVKPA	DEG_SIAH_1	0.0556
p.W669L	DO24780	LUAD	ICGC	QPCAPVKPA	DEG_SIAH_1	0.0556
p.P660L	TCGA-4X-A9FD	THYM	TCGA	QPCAPVKPA	DEG_SIAH_1	0.3056
p.P650S	TCGA-D3-A5GO	SKCM	TCGA	QPCAPVKPA	DEG_SIAH_1	0.3056
p.P650S	DO47419	SKCM	ICGC	QPCAPVKPA	DEG_SIAH_1	0.3056
p.P655T	TCGA-GN-A262	SKCM	TCGA	QPCAPVKPA	DEG_SIAH_1	0.5919
p.P655T	DO37515	SKCM	ICGC	QPCAPVKPA	DEG_SIAH_1	0.5919
p.P660Q	DO35749	PBCA	ICGC	QPCAPVKPA	DEG_SIAH_1	0.3056
p.P667S	DO232224	PBCA	ICGC	QPCAPVKPA	DEG_SIAH_1	0.1111
p.Q651H	DO229248	THCA	ICGC	QPCAPVKPA	DEG_SIAH_1	0.647
p.V656A	DO229242	THCA	ICGC	QPCAPVKPA	DEG_SIAH_1	0.6936
p.P655L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	QPCAPVKPA	DEG_SIAH_1	0.6471
p.P655L	ACH-000981	Leukemia	CCLE	QPCAPVKPA	DEG_SIAH_1	0.6471
p.P655L	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	QPCAPVKPA	DEG_SIAH_1	0.6471
p.S663T	SIDM00501	Oral Cavity Carcinoma	GDSC	QPCAPVKPA	DEG_SIAH_1	0.2222
p.S663T	BICR78	upper_aerodigestive_tract	COSMIC	QPCAPVKPA	DEG_SIAH_1	0.2222
p.Q643E	SIDM00210	Ovarian Carcinoma	GDSC	QPCAPVKPA	DEG_SIAH_1	0.1111
p.Q643E	ACH-000657	Ovarian Cancer	CCLE	QPCAPVKPA	DEG_SIAH_1	0.1111
p.Q643E	A2780	ovary	COSMIC	QPCAPVKPA	DEG_SIAH_1	0.1111
p.Q643H	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	QPCAPVKPA	DEG_SIAH_1	0.1111
p.Q643H	Calu-6	lung	COSMIC	QPCAPVKPA	DEG_SIAH_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCX5	Rhophilin-1	DEG_SIAH_1	651:659	QPCAPVKPA	SIAH1,SIAH2,SIAH3	0.9786	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons