DegronMD - Q9HCJ0(TNRC6C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P162L	TCGA-A5-A0G2	UCEC	TCGA	PQTST	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.7582
p.P162L	DO41235	UCEC	ICGC	PQTST	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.7582
p.T164M	TCGA-A8-A07W	BRCA	TCGA	PQTST	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.7423
p.T164M	DO1297	BRCA	ICGC	PQTST	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.7423
p.S167Y	TCGA-AA-3984	COAD	TCGA	PQTST	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.S167Y	DO9002	COAD	ICGC	PQTST	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.S171Y	TCGA-AG-A002	READ	TCGA	PQTST	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.L1428I	TCGA-AX-A0J1	UCEC	TCGA	DVTPGSVPTGP	DEG_COP1_1	1408:1418	Mutation rewiring degron network	0.0556
p.L1428I	DO41199	UCEC	ICGC	DVTPGSVPTGP	DEG_COP1_1	1408:1418	Mutation rewiring degron network	0.0556
p.A1599V	TCGA-BR-4362	STAD	TCGA	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation rewiring degron network	0.3056
p.A1599V	DO38336	STAD	ICGC	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation rewiring degron network	0.3056
p.V1406I	TCGA-D3-A8GC	SKCM	TCGA	DVTPGSVPTGP	DEG_COP1_1	1408:1418	Mutation rewiring degron network	0.2778
p.V1406I	DO50281	SKCM	ICGC	DVTPGSVPTGP	DEG_COP1_1	1408:1418	Mutation rewiring degron network	0.2778
p.A591G	TCGA-DS-A1OD	CESC	TCGA	ADSSS	DEG_SPOP_SBC_1	600:604	Mutation rewiring degron network	0.0833
p.A591G	DO6299	CESC	ICGC	ADSSS	DEG_SPOP_SBC_1	600:604	Mutation rewiring degron network	0.0833
p.N1612S	TCGA-E6-A1LX	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation rewiring degron network	0.1111
p.N1612S	DO41020	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation rewiring degron network	0.1111
p.W599R	TCGA-EE-A2GO	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	600:604	Mutation rewiring degron network	0.3056
p.W599R	DO37823	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	600:604	Mutation rewiring degron network	0.3056
p.Q1602K	TCGA-FS-A1ZP	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation altering degron motif	0.6944
p.Q1602K	DO37703	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation altering degron motif	0.6944
p.E158K	TCGA-FU-A23L	CESC	TCGA	PQTST	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.E158K	DO6278	CESC	ICGC	PQTST	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.P1415R	TCGA-UZ-A9PN	KIRP	TCGA	DVTPGSVPTGP	DEG_COP1_1	1408:1418	Mutation altering degron motif	0.7512
p.P1415R	DO219703	KIRP	ICGC	DVTPGSVPTGP	DEG_COP1_1	1408:1418	Mutation altering degron motif	0.7512
p.A1666T	DO222842	COCA	ICGC	PTPLTT	DEG_SCF_FBW7_1	1673:1678	Mutation rewiring degron network	0.1389
p.W1669R	DO233113	GACA	ICGC	PTPLTT	DEG_SCF_FBW7_1	1673:1678	Mutation rewiring degron network	0.2222
p.V1411I	DO233126	GACA	ICGC	DVTPGSVPTGP	DEG_COP1_1	1408:1418	Mutation altering degron motif	0.7076
p.G1675S	DO233867	GACA	ICGC	PTPLTT	DEG_SCF_FBW7_1	1673:1678	Mutation altering degron motif	0.6993
p.V170L	DO228976	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.A174S	DO229026	LICA	ICGC	PQTST	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1111
p.R1591L	DO229034	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation rewiring degron network	0.0833
p.E1401V	DO27959	ORCA	ICGC	DVTPGSVPTGP	DEG_COP1_1	1408:1418	Mutation rewiring degron network	0.1389
p.S1664G	DO229221	THCA	ICGC	PTPLTT	DEG_SCF_FBW7_1	1673:1678	Mutation rewiring degron network	0.0833
p.P1672L	DO229245	THCA	ICGC	PTPLTT	DEG_SCF_FBW7_1	1673:1678	Mutation rewiring degron network	0.3056
p.P1672L	SIDM01079	Melanoma	GDSC	PTPLTT	DEG_SCF_FBW7_1	1673:1678	Mutation rewiring degron network	0.3056
p.V1590I	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation rewiring degron network	0.0556
p.V1590I	ACH-000920	Leukemia	CCLE	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation rewiring degron network	0.0556
p.V1590I	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation rewiring degron network	0.0556
p.T1420A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	DVTPGSVPTGP	DEG_COP1_1	1408:1418	Mutation rewiring degron network	0.2778
p.T1420A	ACH-000914	Lymphoma	CCLE	DVTPGSVPTGP	DEG_COP1_1	1408:1418	Mutation rewiring degron network	0.2778
p.T1420A	HT	haematopoietic and lymphoid tissue	COSMIC	DVTPGSVPTGP	DEG_COP1_1	1408:1418	Mutation rewiring degron network	0.2778
p.G610W	SIDM00373	Endometrial Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	600:604	Mutation rewiring degron network	0.1667
p.G610W	ACH-000974	Endometrial/Uterine Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	600:604	Mutation rewiring degron network	0.1667
p.S603L	SIDM00545	Melanoma	GDSC	ADSSS	DEG_SPOP_SBC_1	600:604	Mutation altering degron motif	0.7667
p.S603L	ACH-000987	Skin Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	600:604	Mutation altering degron motif	0.7667
p.S603L	Mewo	skin	COSMIC	ADSSS	DEG_SPOP_SBC_1	600:604	Mutation altering degron motif	0.7667
p.A174V	SIDM00845	Burkitt's Lymphoma	GDSC	PQTST	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1111
p.A174V	SIDM00461	Acute Myeloid Leukemia	GDSC	PQTST	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1111
p.A174V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PQTST	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1111
p.A174V	SIDM01519	Head and Neck Carcinoma	GDSC	PQTST	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1111
p.A174V	ACH-000786	Lymphoma	CCLE	PQTST	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1111
p.A174V	ACH-000992	Head and Neck Cancer	CCLE	PQTST	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1111
p.A174V	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQTST	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1111
p.S1594F	SIDM01175	Other Sarcomas	GDSC	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation rewiring degron network	0.1667
p.S1594F	ACH-002309	Sarcoma	CCLE	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation rewiring degron network	0.1667
p.S1594F	SW684	soft tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation rewiring degron network	0.1667
p.K613E	SIDM00660	Colorectal Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	600:604	Mutation substituting flanking lysine	0.1944
p.K613E	SIDM01113	Other Sarcomas	GDSC	ADSSS	DEG_SPOP_SBC_1	600:604	Mutation substituting flanking lysine	0.1944
p.K613R	SIDM00660	Colorectal Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	600:604	Mutation substituting flanking lysine	0.1944
p.G1686R	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PTPLTT	DEG_SCF_FBW7_1	1673:1678	Mutation rewiring degron network	0.1111
p.D598G	SIDM01450	Gastric Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	600:604	Mutation rewiring degron network	0.2778
p.D598G	ACH-000898	Gastric Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	600:604	Mutation rewiring degron network	0.2778
p.A1671P	SIDM01442	Glioma	GDSC	PTPLTT	DEG_SCF_FBW7_1	1673:1678	Mutation rewiring degron network	0.2778
p.P1600T	ACH-000756	Brain Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation altering degron motif	0.7031
p.P1600T	GI-1	central nervous system	COSMIC	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation altering degron motif	0.7031
p.P176L	ACH-001378	Pancreatic Cancer	CCLE	PQTST	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.0556
p.T1423A	HT	haematopoietic and lymphoid tissue	COSMIC	DVTPGSVPTGP	DEG_COP1_1	1408:1418	Mutation rewiring degron network	0.1944
p.E162K	NCI-H441	lung	COSMIC	PQTST	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.7022
p.A1667S	Capan-2	pancreas	COSMIC	PTPLTT	DEG_SCF_FBW7_1	1673:1678	Mutation rewiring degron network	0.1667
p.A1667S	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PTPLTT	DEG_SCF_FBW7_1	1673:1678	Mutation rewiring degron network	0.1667
p.A1685T	H513	pleura	COSMIC	PTPLTT	DEG_SCF_FBW7_1	1673:1678	Mutation rewiring degron network	0.1389
p.N1599S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	1600:1604	Mutation rewiring degron network	0.3056
p.K1428E	LNCaP-Clone-FGC	prostate	COSMIC	DVTPGSVPTGP	DEG_COP1_1	1408:1418	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNRC6C

UniProt ID: Q9HCJ0

Entrez ID: 57690

Protein name: Trinucleotide repeat-containing gene 6C protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNRC6C in