DegronMD

Uniprot ID: Q9HCJ0

Source protein: Trinucleotide repeat-containing gene 6C protein

Source gene: TNRC6C

Class: DEG_SCF_FBW7_1

Location: 1673:1678

E3 ligase: FBXW7

DEGRON score: 0.9927

ASA_SCORE: 55.8333

COIL: 0.7667

CONS_SCORE: 0.5421

DSS_SCORE: 0.4571

HELIX: 0.1562

FCONS_SCORE: 0.9859

RIG_SCORE: 0.733

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1666T	DO222842	COCA	ICGC	PTPLTT	DEG_SCF_FBW7_1	0.1389
p.W1669R	DO233113	GACA	ICGC	PTPLTT	DEG_SCF_FBW7_1	0.2222
p.G1675S	DO233867	GACA	ICGC	PTPLTT	DEG_SCF_FBW7_1	0.6993
p.S1664G	DO229221	THCA	ICGC	PTPLTT	DEG_SCF_FBW7_1	0.0833
p.P1672L	DO229245	THCA	ICGC	PTPLTT	DEG_SCF_FBW7_1	0.3056
p.P1672L	SIDM01079	Melanoma	GDSC	PTPLTT	DEG_SCF_FBW7_1	0.3056
p.G1686R	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PTPLTT	DEG_SCF_FBW7_1	0.1111
p.A1671P	SIDM01442	Glioma	GDSC	PTPLTT	DEG_SCF_FBW7_1	0.2778
p.A1667S	Capan-2	pancreas	COSMIC	PTPLTT	DEG_SCF_FBW7_1	0.1667
p.A1667S	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	PTPLTT	DEG_SCF_FBW7_1	0.1667
p.A1685T	H513	pleura	COSMIC	PTPLTT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SCF_FBW7_1	1673:1678	PTPLTT	FBXW7	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons