DegronMD

Uniprot ID: Q9HCJ0

Source protein: Trinucleotide repeat-containing gene 6C protein

Source gene: TNRC6C

Class: DEG_SPOP_SBC_1

Location: 600:604

E3 ligase: SPOP

DEGRON score: 0.9818

ASA_SCORE: 75.08

COIL: 0.823

CONS_SCORE: 0.3571

DSS_SCORE: 0.5401

HELIX: 0.1634

FCONS_SCORE: 0.9926

RIG_SCORE: 0.7086

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S603L	SIDM00545	Melanoma	GDSC	ADSSS	DEG_SPOP_SBC_1	0.7667
p.S603L	ACH-000987	Skin Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	0.7667
p.S603L	Mewo	skin	COSMIC	ADSSS	DEG_SPOP_SBC_1	0.7667
p.W599R	TCGA-EE-A2GO	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	0.3056
p.W599R	DO37823	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	0.3056
p.D598G	SIDM01450	Gastric Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	0.2778
p.D598G	ACH-000898	Gastric Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	0.2778
p.K613E	SIDM00660	Colorectal Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	0.1944
p.K613E	SIDM01113	Other Sarcomas	GDSC	ADSSS	DEG_SPOP_SBC_1	0.1944
p.K613R	SIDM00660	Colorectal Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	0.1944
p.G610W	SIDM00373	Endometrial Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	0.1667
p.G610W	ACH-000974	Endometrial/Uterine Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	0.1667
p.A591G	TCGA-DS-A1OD	CESC	TCGA	ADSSS	DEG_SPOP_SBC_1	0.0833
p.A591G	DO6299	CESC	ICGC	ADSSS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 14 of 14 entries

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Drug responses associated with TNRC6C mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of ADSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	494:498	ADSSS	SPOP	0.9841	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_SPOP_SBC_1	1171:1175	ADSSS	SPOP	0.8432	More...
Q9UKV3	Apoptotic chromatin condensation inducer in the nucleus	DEG_SPOP_SBC_1	574:578	ADSSS	SPOP	0.9639	More...
Q8NA72	Centrosomal protein POC5	DEG_SPOP_SBC_1	127:131	ADSSS	SPOP	0.8228	More...
P45973	Chromobox protein homolog 5	DEG_SPOP_SBC_1	9:13	ADSSS	SPOP	0.9016	More...
Q99941	Cyclic AMP-dependent transcription factor ATF-6 beta	DEG_SPOP_SBC_1	183:187	ADSSS	SPOP	0.9951	More...
Q03468	DNA excision repair protein ERCC-6	DEG_SPOP_SBC_1	1377:1381	ADSSS	SPOP	0.9914	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	929:933	ADSSS	SPOP	0.6557	More...
Q13480	GRB2-associated-binding protein 1	DEG_SPOP_SBC_1	151:155	ADSSS	SPOP	0.9969	More...
O14654	Insulin receptor substrate 4	DEG_SPOP_SBC_1	915:919	ADSSS	SPOP	0.9969	More...
P98153	Integral membrane protein DGCR2/IDD	DEG_SPOP_SBC_1	511:515	ADSSS	SPOP	0.9946	More...
O43187	Interleukin-1 receptor-associated kinase-like 2	DEG_SPOP_SBC_1	573:577	ADSSS	SPOP	0.6187	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	82:86	ADSSS	SPOP	0.9679	More...
Q969V6	Myocardin-related transcription factor A	DEG_SPOP_SBC_1	110:114	ADSSS	SPOP	0.9951	More...
O95248	Myotubularin-related protein 5	DEG_SPOP_SBC_1	1235:1239	ADSSS	SPOP	0.5133	More...
O15069	NAC-alpha domain-containing protein 1	DEG_SPOP_SBC_1	282:286	ADSSS	SPOP	0.9969	More...
Q86W24	NACHT, LRR and PYD domains-containing protein 14	DEG_SPOP_SBC_1	2:6	ADSSS	SPOP	0.8095	More...
Q14978	Nucleolar and coiled-body phosphoprotein 1	DEG_SPOP_SBC_1	421:425	ADSSS	SPOP	0.9888	More...
P40197	Platelet glycoprotein V	DEG_SPOP_SBC_1	484:488	ADSSS	SPOP	0.6617	More...
Q9NP73	Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13	DEG_SPOP_SBC_1	1055:1059	ADSSS	SPOP	0.9769	More...
A0MZ66	Shootin-1	DEG_SPOP_SBC_1	490:494	ADSSS	SPOP	0.992	More...
Q66K14	TBC1 domain family member 9B	DEG_SPOP_SBC_1	355:359	ADSSS	SPOP	0.7361	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	19877:19881	ADSSS	SPOP	0.7426	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	196:200	ADSSS	SPOP	0.9906	More...
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	DEG_SPOP_SBC_1	600:604	ADSSS	SPOP	0.9818	More...

Showing 1 to 25 of 28 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ADSSS

Degron related mutations and impact score

Drug responses associated with TNRC6C mutations

All proteins holding degron of ADSSS