DegronMD - Q969V6(MRTFA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L859R	SIDM02039	Colorectal Carcinoma	GDSC	DTSELHFVPEP	DEG_COP1_1	862:872	Mutation rewiring degron network	0.25
p.I123V	SIDM00653	Small Cell Lung Carcinoma	GDSC	SHESQGSVPSP	DEG_COP1_1	130:140	Mutation rewiring degron network	0.1389
p.I123V	SIDM00653	Small Cell Lung Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.0833
p.I123V	NCI-H1092	lung	COSMIC	SHESQGSVPSP	DEG_COP1_1	130:140	Mutation rewiring degron network	0.1389
p.I123V	NCI-H1092	lung	COSMIC	ADSSS	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.0833
p.G912D	SIDM00217	Colorectal Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.2222
p.G912D	SNU-1040	large intestine	COSMIC	PLSTT	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.2222
p.Q722K	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPGY	ITCH	725:728	Mutation substituting flanking lysine	0.3611
p.Q722K	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	725:728	Mutation substituting flanking lysine	0.3611
p.N140T	SIDM01378	Ovarian Carcinoma	GDSC	SHESQGSVPSP	DEG_COP1_1	130:140	Mutation altering degron motif	0.7055
p.P125L	NCI-H1770	lung	COSMIC	SHESQGSVPSP	DEG_COP1_1	130:140	Mutation rewiring degron network	0.1944
p.R145G	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	SHESQGSVPSP	DEG_COP1_1	130:140	Mutation rewiring degron network	0.1944
p.F138L	CW-2	large intestine	COSMIC	SHESQGSVPSP	DEG_COP1_1	130:140	Mutation altering degron motif	0.6981
p.P126L	NCI-H1770	lung	COSMIC	SHESQGSVPSP	DEG_COP1_1	130:140	Mutation rewiring degron network	0.2222
p.R144G	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	SHESQGSVPSP	DEG_COP1_1	130:140	Mutation rewiring degron network	0.2222
p.G877D	SNU-1040	large intestine	COSMIC	DTSELHFVPEP	DEG_COP1_1	862:872	Mutation rewiring degron network	0.1944
p.S141I	LU-65	lung	COSMIC	SHESQGSVPSP	DEG_COP1_1	130:140	Mutation rewiring degron network	0.3056
p.C733Y	MFE-319	endometrium	COSMIC	PPGY	ITCH	725:728	Mutation rewiring degron network	0.1944
p.C734Y	MFE-319	endometrium	COSMIC	PPGY	ITCH	725:728	Mutation rewiring degron network	0.1667
p.D878N	MDA-MB-361	breast	COSMIC	DTSELHFVPEP	DEG_COP1_1	862:872	Mutation rewiring degron network	0.1667
p.D879N	MDA-MB-361	breast	COSMIC	DTSELHFVPEP	DEG_COP1_1	862:872	Mutation rewiring degron network	0.1389
p.G101D	DU-145	prostate	COSMIC	ADSSS	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.0833

Kaplan plot for MRTFA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MRTFA

UniProt ID: Q969V6

Entrez ID: 57591

Protein name: Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MRTFA in