DegronMD

Uniprot ID: Q969V6

Source protein: Myocardin-related transcription factor A

Source gene: MRTFA

Class: DEG_COP1_1

Location: 130:140

E3 ligase: COP1

DEGRON score: 0.7071

ASA_SCORE: 84.6182

COIL: 0.904

CONS_SCORE: 0.3484

DSS_SCORE: 0.7375

HELIX: 0.0727

FCONS_SCORE: 0.8085

RIG_SCORE: 0.5475

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I123V	SIDM00653	Small Cell Lung Carcinoma	GDSC	SHESQGSVPSP	DEG_COP1_1	0.1389
p.I123V	NCI-H1092	lung	COSMIC	SHESQGSVPSP	DEG_COP1_1	0.1389
p.N140T	SIDM01378	Ovarian Carcinoma	GDSC	SHESQGSVPSP	DEG_COP1_1	0.7055
p.P125L	NCI-H1770	lung	COSMIC	SHESQGSVPSP	DEG_COP1_1	0.1944
p.R145G	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SHESQGSVPSP	DEG_COP1_1	0.1944
p.F138L	CW-2	large_intestine	COSMIC	SHESQGSVPSP	DEG_COP1_1	0.6981
p.P126L	NCI-H1770	lung	COSMIC	SHESQGSVPSP	DEG_COP1_1	0.2222
p.R144G	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SHESQGSVPSP	DEG_COP1_1	0.2222
p.S141I	LU-65	lung	COSMIC	SHESQGSVPSP	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969V6	Myocardin-related transcription factor A	DEG_COP1_1	130:140	SHESQGSVPSP	COP1	0.7071	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons