DegronMD

Uniprot ID: Q969V6

Source protein: Myocardin-related transcription factor A

Source gene: MRTFA

Class: DEG_COP1_1

Location: 862:872

E3 ligase: COP1

DEGRON score: 0.9762

ASA_SCORE: 93.0909

COIL: 0.8377

CONS_SCORE: 0.4148

DSS_SCORE: 0.6036

HELIX: 0.1331

FCONS_SCORE: 1.0655

RIG_SCORE: 0.6824

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L859R	SIDM02039	Colorectal Carcinoma	GDSC	DTSELHFVPEP	DEG_COP1_1	0.25
p.G877D	SNU-1040	large_intestine	COSMIC	DTSELHFVPEP	DEG_COP1_1	0.1944
p.D878N	MDA-MB-361	breast	COSMIC	DTSELHFVPEP	DEG_COP1_1	0.1667
p.D879N	MDA-MB-361	breast	COSMIC	DTSELHFVPEP	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969V6	Myocardin-related transcription factor A	DEG_COP1_1	862:872	DTSELHFVPEP	COP1	0.9762	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons