DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PLSTT
Uniprot ID:
Q969V6
Source protein:
Myocardin-related transcription factor A
Source gene:
MRTFA
Class:
DEG_SPOP_SBC_1
Location:
904:908
E3 ligase:
SPOP
DEGRON score:
0.931
ASA_SCORE:
76.48
COIL:
0.9194
CONS_SCORE:
0.3842
DSS_SCORE:
0.2174
HELIX:
0.0244
FCONS_SCORE:
0.9751
RIG_SCORE:
0.7322
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G912D
SIDM00217
Colorectal Carcinoma
GDSC
PLSTT
DEG_SPOP_SBC_1
0.2222
p.G912D
SNU-1040
large_intestine
COSMIC
PLSTT
DEG_SPOP_SBC_1
0.2222
Drug responses associated with MRTFA mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PLSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94910
Adhesion G protein-coupled receptor L1
DEG_SPOP_SBC_1
410:414
PLSTT
SPOP
0.9976
More...
O94991
SLIT and NTRK-like protein 5
DEG_SPOP_SBC_1
299:303
PLSTT
SPOP
0.9511
More...
O95319
CUGBP Elav-like family member 2
DEG_SPOP_SBC_1
304:308
PLSTT
SPOP
0.7964
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
2108:2112
PLSTT
SPOP
0.6286
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
3464:3468
PLSTT
SPOP
0.5305
More...
Q969V6
Myocardin-related transcription factor A
DEG_SPOP_SBC_1
904:908
PLSTT
SPOP
0.931
More...
Q9NZP6
Nuclear pore-associated protein 1
DEG_SPOP_SBC_1
443:447
PLSTT
SPOP
0.9874
More...
Q9ULH7
Myocardin-related transcription factor B
DEG_SPOP_SBC_1
1064:1068
PLSTT
SPOP
0.9334
More...
Q9Y3S1
Serine/threonine-protein kinase WNK2
DEG_SPOP_SBC_1
2228:2232
PLSTT
SPOP
0.9645
More...
O60347
TBC1 domain family member 12
DEG_SPOP_SBC_1
391:395
PLSTT
SPOP
0.9367
More...
Q9P1G2
Putative uncharacterized protein encoded by RBM12B-AS1
DEG_SPOP_SBC_1
24:28
PLSTT
SPOP
0.9186
More...