DegronMD

Uniprot ID: Q9NZP6

Source protein: Nuclear pore-associated protein 1

Source gene: NPAP1

Class: DEG_SPOP_SBC_1

Location: 443:447

E3 ligase: SPOP

DEGRON score: 0.9874

ASA_SCORE: 86.38

COIL: 0.96

CONS_SCORE: 0.5352

DSS_SCORE: 0.3733

HELIX: 0.0194

FCONS_SCORE: 0.9217

RIG_SCORE: 0.7075

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L439M	TCGA-58-A46N	LUSC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.2222
p.L439M	DO45460	LUSC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.2222
p.L439M	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.2222
p.L439M	ACH-000951	Lung Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.2222
p.L439M	NCI-H2342	lung	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.2222
p.T457P	TCGA-AA-A00N	COAD	TCGA	PLSTT	DEG_SPOP_SBC_1	0.0556
p.T457P	DO9876	COAD	ICGC	PLSTT	DEG_SPOP_SBC_1	0.0556
p.K449N	TCGA-AZ-4315	COAD	TCGA	PLSTT	DEG_SPOP_SBC_1	0.2778
p.K449N	DO8842	COAD	ICGC	PLSTT	DEG_SPOP_SBC_1	0.2778
p.L437I	TCGA-BA-4076	HNSC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1667
p.L437I	DO14502	HNSC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1667
p.A433V	TCGA-BF-AAOX	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	0.0556
p.A433V	DO223907	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	0.0556
p.P436T	TCGA-CN-4739	HNSC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1389
p.P436T	DO14478	HNSC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.P436L	TCGA-D3-A3ML	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1389
p.P436L	DO47413	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.T447P	TCGA-D6-6516	HNSC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.7031
p.T447P	DO15623	HNSC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7031
p.L444F	TCGA-D9-A1JW	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	0.587
p.L444F	DO37786	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	0.587
p.T446I	TCGA-EE-A183	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	0.7078
p.T446I	DO37715	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7078
p.P442S	TCGA-EE-A2M8	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	0.3056
p.P442S	DO38075	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	0.3056
p.P443L	TCGA-ER-A194	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	0.7582
p.P443L	DO47646	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7582
p.M450I	TCGA-O2-A52S	LUSC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.25
p.M450I	TCGA-YD-A9TB	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	0.25
p.M450I	DO219221	LUSC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.25
p.M450I	DO51297	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	0.25
p.E452D	TCGA-ZF-AA51	BLCA	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1944
p.E452D	DO219093	BLCA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.E452G	DO233897	GACA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.A455S	SIDM00120	Prostate Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1111
p.A455S	ACH-000979	Prostate Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.1111
p.A455S	DU-145	prostate	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1111
p.P440R	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.25
p.P440R	ACH-002220	Lymphoma	CCLE	PLSTT	DEG_SPOP_SBC_1	0.25
p.P440R	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.25
p.P440H	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.25
p.P440H	ACH-000843	Lung Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.25
p.P440H	HARA	lung	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.25
p.E452A	SIDM00534	Colorectal Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.E452A	ACH-000986	Colon/Colorectal Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.1944
p.E452A	HT-115	large_intestine	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.L437R	ACH-001518	Endometrial/Uterine Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94910	Adhesion G protein-coupled receptor L1	DEG_SPOP_SBC_1	410:414	PLSTT	SPOP	0.9976	More...
O94991	SLIT and NTRK-like protein 5	DEG_SPOP_SBC_1	299:303	PLSTT	SPOP	0.9511	More...
O95319	CUGBP Elav-like family member 2	DEG_SPOP_SBC_1	304:308	PLSTT	SPOP	0.7964	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2108:2112	PLSTT	SPOP	0.6286	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3464:3468	PLSTT	SPOP	0.5305	More...
Q969V6	Myocardin-related transcription factor A	DEG_SPOP_SBC_1	904:908	PLSTT	SPOP	0.931	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	443:447	PLSTT	SPOP	0.9874	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	1064:1068	PLSTT	SPOP	0.9334	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2228:2232	PLSTT	SPOP	0.9645	More...
O60347	TBC1 domain family member 12	DEG_SPOP_SBC_1	391:395	PLSTT	SPOP	0.9367	More...
Q9P1G2	Putative uncharacterized protein encoded by RBM12B-AS1	DEG_SPOP_SBC_1	24:28	PLSTT	SPOP	0.9186	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSTT

Degron related mutations and impact score

Drug responses associated with NPAP1 mutations

All proteins holding degron of PLSTT