DegronMD - Q9ULH7(MRTFB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R884C	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPRY	ITCH	871:874	Mutation rewiring degron network	0.0556
p.R884C	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PPRY	ITCH	871:874	Mutation rewiring degron network	0.0556
p.R884C	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPRY	ITCH	871:874	Mutation rewiring degron network	0.0556
p.R884C	NCI-H630	large intestine	COSMIC	PPRY	ITCH	871:874	Mutation rewiring degron network	0.0556
p.P432L	SIDM00126	Melanoma	GDSC	AVSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1944
p.P432L	SIDM00126	Melanoma	GDSC	LKPYQE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1111
p.P432L	K2	skin	COSMIC	AVSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.1944
p.P432L	K2	skin	COSMIC	LKPYQE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1111
p.S552R	SIDM00542	Glioblastoma	GDSC	PTSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.S552R	D-392MG	central nervous system	COSMIC	PTSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.2222
p.E411G	SIDM00217	Colorectal Carcinoma	GDSC	LKPYQE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1111
p.E411G	SNU-1040	large intestine	COSMIC	LKPYQE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.1111
p.I427N	SIDM00877	Breast Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.0556
p.I427N	SIDM00877	Breast Carcinoma	GDSC	LKPYQE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.25
p.I427N	HCC1599	breast	COSMIC	AVSSS	DEG_SPOP_SBC_1	437:441	Mutation rewiring degron network	0.0556
p.I427N	HCC1599	breast	COSMIC	LKPYQE	LIG_APCC_ABBA_1	419:424	Mutation rewiring degron network	0.25
p.Q537E	SIDM00205	Ewing's Sarcoma	GDSC	PTSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.1389
p.Q537E	EW-1	bone	COSMIC	PTSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.1389
p.N549S	SIDM00118	Colorectal Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.3056
p.N549S	HCC2998	large intestine	COSMIC	PTSST	DEG_SPOP_SBC_1	544:548	Mutation rewiring degron network	0.3056
p.V867I	SIDM00515	Melanoma	GDSC	PPRY	ITCH	871:874	Mutation substituting flanking lysine	0.3333
p.V867I	COLO-800	skin	COSMIC	PPRY	ITCH	871:874	Mutation substituting flanking lysine	0.3333
p.R884G	EW-11	bone	COSMIC	PPRY	ITCH	871:874	Mutation rewiring degron network	0.0556
p.H229R	SNU-1040	large intestine	COSMIC	SVSPTVPEF	DEG_COP1_1	223:231	Mutation altering degron motif	0.8244

Kaplan plot for MRTFB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MRTFB

UniProt ID: Q9ULH7

Entrez ID: 57496

Protein name: Myocardin-related transcription factor B (MRTF-B) (MKL/myocardin-like protein 2) (Megakaryoblastic leukemia 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MRTFB in