DegronMD

Uniprot ID: Q9ULH7

Source protein: Myocardin-related transcription factor B

Source gene: MRTFB

Class: LIG_APCC_ABBA_1

Location: 419:424

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8669

ASA_SCORE: 101.5667

COIL: 0.6877

CONS_SCORE: 0.5967

DSS_SCORE: 0.3503

HELIX: 0.2887

FCONS_SCORE: 1.1761

RIG_SCORE: 0.8207

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P432L	SIDM00126	Melanoma	GDSC	LKPYQE	LIG_APCC_ABBA_1	0.1111
p.P432L	K2	skin	COSMIC	LKPYQE	LIG_APCC_ABBA_1	0.1111
p.E411G	SIDM00217	Colorectal Carcinoma	GDSC	LKPYQE	LIG_APCC_ABBA_1	0.1111
p.E411G	SNU-1040	large_intestine	COSMIC	LKPYQE	LIG_APCC_ABBA_1	0.1111
p.I427N	SIDM00877	Breast Carcinoma	GDSC	LKPYQE	LIG_APCC_ABBA_1	0.25
p.I427N	HCC1599	breast	COSMIC	LKPYQE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULH7	Myocardin-related transcription factor B	LIG_APCC_ABBA_1	419:424	LKPYQE	APC,CDC20,FZR1	0.8669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons