DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
SVSPTVPEF
Uniprot ID:
Q9ULH7
Source protein:
Myocardin-related transcription factor B
Source gene:
MRTFB
Class:
DEG_COP1_1
Location:
223:231
E3 ligase:
COP1
DEGRON score:
0.9892
ASA_SCORE:
94.2111
COIL:
0.9316
CONS_SCORE:
0.4768
DSS_SCORE:
0.5979
HELIX:
0.0421
FCONS_SCORE:
1.1414
RIG_SCORE:
0.6759
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H229R
SNU-1040
large_intestine
COSMIC
SVSPTVPEF
DEG_COP1_1
0.8244
Drug responses associated with MRTFB mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SVSPTVPEF
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9ULH7
Myocardin-related transcription factor B
DEG_COP1_1
223:231
SVSPTVPEF
COP1
0.9892
More...