DegronMD

Uniprot ID: O94991

Source protein: SLIT and NTRK-like protein 5

Source gene: SLITRK5

Class: DEG_SPOP_SBC_1

Location: 299:303

E3 ligase: SPOP

DEGRON score: 0.9511

ASA_SCORE: 49.56

COIL: 0.78

CONS_SCORE: 0.6506

DSS_SCORE: 0.5258

HELIX: 0.1016

FCONS_SCORE: 1.0328

RIG_SCORE: 0.6899

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E293K	TCGA-18-3409	LUSC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1667
p.E293K	TCGA-A6-5661	COAD	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1667
p.P310Q	TCGA-43-2576	LUSC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1389
p.T308N	TCGA-44-3918	LUAD	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1944
p.P310L	TCGA-D1-A167	UCEC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1389
p.P310L	SIDM01560	Rhabdomyosarcoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1389
p.L306S	TCGA-EY-A214	UCEC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.25
p.T303M	TCGA-IG-A97I	ESCA	TCGA	PLSTT	DEG_SPOP_SBC_1	0.7423
p.T303M	TCGA-L5-A4OI	ESCA	TCGA	PLSTT	DEG_SPOP_SBC_1	0.7423
p.E293D	TCGA-N9-A4Q7	UCS	TCGA	PLSTT	DEG_SPOP_SBC_1	0.1667
p.H307Y	TCGA-VS-A8EC	CESC	TCGA	PLSTT	DEG_SPOP_SBC_1	0.2222
p.H307Y	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PLSTT	DEG_SPOP_SBC_1	0.2222
p.H307Y	ACH-000937	Leukemia	CCLE	PLSTT	DEG_SPOP_SBC_1	0.2222
p.H307Y	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.2222
p.L302V	DO8842	COAD	ICGC	PLSTT	DEG_SPOP_SBC_1	0.6765
p.L302V	DO46657	PAAD	ICGC	PLSTT	DEG_SPOP_SBC_1	0.6765
p.L302F	DO8546	COAD	ICGC	PLSTT	DEG_SPOP_SBC_1	0.6981
p.L302F	DO229031	LICA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.6981
p.D309E	DO233178	GACA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1667
p.S301F	DO233762	GACA	ICGC	PLSTT	DEG_SPOP_SBC_1	0.7982
p.L290P	DO18016	KIRC	ICGC	PLSTT	DEG_SPOP_SBC_1	0.0833
p.R291M	DO23629	LUAD	ICGC	PLSTT	DEG_SPOP_SBC_1	0.1111
p.P299H	SIDM02016	Colorectal Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.7694
p.T308I	SIDM00453	Pancreatic Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	0.1944
p.T308I	ACH-000023	Pancreatic Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	0.1944
p.T308I	PA-TU-8988T	pancreas	COSMIC	PLSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94910	Adhesion G protein-coupled receptor L1	DEG_SPOP_SBC_1	410:414	PLSTT	SPOP	0.9976	More...
O94991	SLIT and NTRK-like protein 5	DEG_SPOP_SBC_1	299:303	PLSTT	SPOP	0.9511	More...
O95319	CUGBP Elav-like family member 2	DEG_SPOP_SBC_1	304:308	PLSTT	SPOP	0.7964	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2108:2112	PLSTT	SPOP	0.6286	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3464:3468	PLSTT	SPOP	0.5305	More...
Q969V6	Myocardin-related transcription factor A	DEG_SPOP_SBC_1	904:908	PLSTT	SPOP	0.931	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	443:447	PLSTT	SPOP	0.9874	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	1064:1068	PLSTT	SPOP	0.9334	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2228:2232	PLSTT	SPOP	0.9645	More...
O60347	TBC1 domain family member 12	DEG_SPOP_SBC_1	391:395	PLSTT	SPOP	0.9367	More...
Q9P1G2	Putative uncharacterized protein encoded by RBM12B-AS1	DEG_SPOP_SBC_1	24:28	PLSTT	SPOP	0.9186	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons