DegronMD - O94991(SLITRK5)

FUNCTION: Suppresses neurite outgrowth. {ECO:0000250}.

GO - Biological processes (BP): axonogenesis [GO:0007409]; regulation of presynapse assembly [GO:1905606]

GO - Molecular function (MF):

GO - Cellular component (CC): integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PQTPLST	DEG_SCF_FBW7_1	FBXW7	SLIT and NTRK-like protein 5	296:302	More..
VVSTPTPS	DEG_SCF_FBW7_1	FBXW7	SLIT and NTRK-like protein 5	619:626	More..
PLSTT	DEG_SPOP_SBC_1	SPOP	SLIT and NTRK-like protein 5	299:303	More..
VATSS	DEG_SPOP_SBC_1	SPOP	SLIT and NTRK-like protein 5	316:320	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S301F	DO233762	GACA	ICGC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7982
p.S320F	SIDM01175	Other Sarcomas	GDSC	VATSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.7982
p.S320F	ACH-002309	Sarcoma	CCLE	VATSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.7982
p.S320F	SW684	soft tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.7982
p.P299H	SIDM02016	Colorectal Carcinoma	GDSC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.7694
p.P299H	SIDM02016	Colorectal Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7694
p.T298M	TCGA-AX-A2HA	UCEC	TCGA	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.7423
p.T298M	TCGA-D5-6928	COAD	TCGA	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.7423
p.T303M	TCGA-IG-A97I	ESCA	TCGA	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7423
p.T303M	TCGA-L5-A4OI	ESCA	TCGA	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7423
p.T622K	SIDM00656	Burkitt's Lymphoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation altering degron motif	0.7306
p.T622K	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation altering degron motif	0.7306
p.T622K	SIDM00641	Burkitt's Lymphoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation altering degron motif	0.7306
p.T298K	SIDM01442	Glioma	GDSC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.7306
p.T298K	ACH-000807	Brain Cancer	CCLE	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.7306
p.S319Y	TCGA-EO-A22U	UCEC	TCGA	VATSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.712
p.L302F	DO8546	COAD	ICGC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.6981
p.L302F	DO8546	COAD	ICGC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.6981
p.L302F	DO229031	LICA	ICGC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.6981
p.L302F	DO229031	LICA	ICGC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.6981

Showing 1 to 20 of 113 entries

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Kaplan plot for SLITRK5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLITRK5

UniProt ID: O94991

Entrez ID: 26050

Protein name: SLIT and NTRK-like protein 5 (Leucine-rich repeat-containing protein 11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLITRK5 in