DegronMD - O94991(SLITRK5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E293K	TCGA-18-3409	LUSC	TCGA	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.25
p.E293K	TCGA-18-3409	LUSC	TCGA	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1667
p.E293K	TCGA-A6-5661	COAD	TCGA	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.25
p.E293K	TCGA-A6-5661	COAD	TCGA	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1667
p.P310Q	TCGA-43-2576	LUSC	TCGA	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.1111
p.P310Q	TCGA-43-2576	LUSC	TCGA	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.P310Q	TCGA-43-2576	LUSC	TCGA	VATSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1667
p.T308N	TCGA-44-3918	LUAD	TCGA	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.1667
p.T308N	TCGA-44-3918	LUAD	TCGA	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1944
p.T308N	TCGA-44-3918	LUAD	TCGA	VATSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1111
p.V618I	TCGA-66-2782	LUSC	TCGA	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.3056
p.P296L	TCGA-69-7980	LUAD	TCGA	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.6471
p.P296L	TCGA-AG-A002	READ	TCGA	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.6471
p.R286S	TCGA-A5-A1OF	UCEC	TCGA	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.0556
p.A636V	TCGA-AA-3695	COAD	TCGA	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.0556
p.A636V	SIDM00217	Colorectal Carcinoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.0556
p.A636V	ACH-000999	Colon/Colorectal Cancer	CCLE	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.0556
p.A636V	SNU-1040	large intestine	COSMIC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.0556
p.C612Y	TCGA-AJ-A3OJ	UCEC	TCGA	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.1389
p.C612Y	TCGA-BK-A13B	UCEC	TCGA	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.1389
p.A632V	TCGA-AP-A05H	UCEC	TCGA	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.1667
p.T298M	TCGA-AX-A2HA	UCEC	TCGA	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.7423
p.T298M	TCGA-D5-6928	COAD	TCGA	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.7423
p.P310L	TCGA-D1-A167	UCEC	TCGA	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.1111
p.P310L	TCGA-D1-A167	UCEC	TCGA	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.P310L	TCGA-D1-A167	UCEC	TCGA	VATSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1667
p.P310L	SIDM01560	Rhabdomyosarcoma	GDSC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.1111
p.P310L	SIDM01560	Rhabdomyosarcoma	GDSC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.P310L	SIDM01560	Rhabdomyosarcoma	GDSC	VATSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1667
p.C612F	TCGA-DX-A6YS	SARC	TCGA	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.1389
p.S319Y	TCGA-EO-A22U	UCEC	TCGA	VATSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.712
p.L306S	TCGA-EY-A214	UCEC	TCGA	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.2222
p.L306S	TCGA-EY-A214	UCEC	TCGA	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.25
p.L306S	TCGA-EY-A214	UCEC	TCGA	VATSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.0556
p.T303M	TCGA-IG-A97I	ESCA	TCGA	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7423
p.T303M	TCGA-L5-A4OI	ESCA	TCGA	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7423
p.T318S	TCGA-MN-A4N4	LUAD	TCGA	VATSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.6005
p.D617Y	TCGA-MP-A4TK	LUAD	TCGA	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.2778
p.E293D	TCGA-N9-A4Q7	UCS	TCGA	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.25
p.E293D	TCGA-N9-A4Q7	UCS	TCGA	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1667
p.H307Y	TCGA-VS-A8EC	CESC	TCGA	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.1944
p.H307Y	TCGA-VS-A8EC	CESC	TCGA	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.2222
p.H307Y	TCGA-VS-A8EC	CESC	TCGA	VATSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.0833
p.H307Y	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.1944
p.H307Y	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.2222
p.H307Y	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VATSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.0833
p.H307Y	ACH-000937	Leukemia	CCLE	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.1944
p.H307Y	ACH-000937	Leukemia	CCLE	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.2222
p.H307Y	ACH-000937	Leukemia	CCLE	VATSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.0833
p.H307Y	PF-382	haematopoietic and lymphoid tissue	COSMIC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.1944
p.H307Y	PF-382	haematopoietic and lymphoid tissue	COSMIC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.2222
p.H307Y	PF-382	haematopoietic and lymphoid tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.0833
p.G286R	DO1110	BRCA	ICGC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.0556
p.L287F	DO6290	CESC	ICGC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.0833
p.L302V	DO8842	COAD	ICGC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.6765
p.L302V	DO8842	COAD	ICGC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.6765
p.L302V	DO46657	PAAD	ICGC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.6765
p.L302V	DO46657	PAAD	ICGC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.6765
p.L302F	DO8546	COAD	ICGC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.6981
p.L302F	DO8546	COAD	ICGC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.6981
p.L302F	DO229031	LICA	ICGC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.6981
p.L302F	DO229031	LICA	ICGC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.6981
p.D309E	DO233178	GACA	ICGC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.1389
p.D309E	DO233178	GACA	ICGC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1667
p.D309E	DO233178	GACA	ICGC	VATSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1389
p.S301F	DO233762	GACA	ICGC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.6871
p.S301F	DO233762	GACA	ICGC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7982
p.L290P	DO18016	KIRC	ICGC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.1667
p.L290P	DO18016	KIRC	ICGC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0833
p.A610S	DO229026	LICA	ICGC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.0833
p.C326S	DO25058	LUAD	ICGC	VATSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1667
p.R291M	DO23629	LUAD	ICGC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.1944
p.R291M	DO23629	LUAD	ICGC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1111
p.D611Y	DO26467	LUSC	ICGC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.1111
p.L633F	DO52674	MALY	ICGC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.1389
p.D609E	DO232071	ORCA	ICGC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.0556
p.D318N	DO36556	READ	ICGC	VATSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.6932
p.G616S	DO46818	RECA	ICGC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.25
p.R615M	DO38404	STAD	ICGC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.2222
p.T627I	DO41602	UCEC	ICGC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.3056
p.P323H	DO41361	UCEC	ICGC	VATSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.25
p.P299H	SIDM02016	Colorectal Carcinoma	GDSC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.7694
p.P299H	SIDM02016	Colorectal Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.7694
p.L610Q	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.0833
p.L610Q	SIDM01181	Hepatocellular Carcinoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.0833
p.L610Q	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.0833
p.L610Q	SIDM01378	Ovarian Carcinoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.0833
p.V619L	SIDM00216	Colorectal Carcinoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation altering degron motif	0.5654
p.V619L	ACH-000989	Colon/Colorectal Cancer	CCLE	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation altering degron motif	0.5654
p.V619L	SNU-175	large intestine	COSMIC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation altering degron motif	0.5654
p.S320F	SIDM01175	Other Sarcomas	GDSC	VATSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.7982
p.S320F	ACH-002309	Sarcoma	CCLE	VATSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.7982
p.S320F	SW684	soft tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.7982
p.V620I	SIDM00594	Acute Myeloid Leukemia	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation altering degron motif	0.5965
p.V620I	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation altering degron motif	0.5965
p.T622K	SIDM00656	Burkitt's Lymphoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation altering degron motif	0.7306
p.T622K	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation altering degron motif	0.7306
p.T622K	SIDM00641	Burkitt's Lymphoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation altering degron motif	0.7306
p.T308I	SIDM00453	Pancreatic Carcinoma	GDSC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.1667
p.T308I	SIDM00453	Pancreatic Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1944
p.T308I	SIDM00453	Pancreatic Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1111
p.T308I	ACH-000023	Pancreatic Cancer	CCLE	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.1667
p.T308I	ACH-000023	Pancreatic Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1944
p.T308I	ACH-000023	Pancreatic Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1111
p.T308I	PA-TU-8988T	pancreas	COSMIC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation rewiring degron network	0.1667
p.T308I	PA-TU-8988T	pancreas	COSMIC	PLSTT	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1944
p.T308I	PA-TU-8988T	pancreas	COSMIC	VATSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1111
p.E609K	SIDM00202	Ewing's Sarcoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.0556
p.E609Q	SIDM00457	Plasma Cell Myeloma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.0556
p.E609Q	ACH-000024	Myeloma	CCLE	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.0556
p.E609Q	OPM-2	haematopoietic and lymphoid tissue	COSMIC	VVSTPTPS	DEG_SCF_FBW7_1	619:626	Mutation rewiring degron network	0.0556
p.T298K	SIDM01442	Glioma	GDSC	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.7306
p.T298K	ACH-000807	Brain Cancer	CCLE	PQTPLST	DEG_SCF_FBW7_1	296:302	Mutation altering degron motif	0.7306

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLITRK5

UniProt ID: O94991

Entrez ID: 26050

Protein name: SLIT and NTRK-like protein 5 (Leucine-rich repeat-containing protein 11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLITRK5 in