DegronMD

Uniprot ID: O94991

Source protein: SLIT and NTRK-like protein 5

Source gene: SLITRK5

Class: DEG_SCF_FBW7_1

Location: 619:626

E3 ligase: FBXW7

DEGRON score: 0.7671

ASA_SCORE: 83.375

COIL: 0.8995

CONS_SCORE: 0.5521

DSS_SCORE: 0.3679

HELIX: 0.0263

FCONS_SCORE: 1.1265

RIG_SCORE: 0.7201

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V618I	TCGA-66-2782	LUSC	TCGA	VVSTPTPS	DEG_SCF_FBW7_1	0.3056
p.A636V	TCGA-AA-3695	COAD	TCGA	VVSTPTPS	DEG_SCF_FBW7_1	0.0556
p.A636V	SIDM00217	Colorectal Carcinoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	0.0556
p.A636V	ACH-000999	Colon/Colorectal Cancer	CCLE	VVSTPTPS	DEG_SCF_FBW7_1	0.0556
p.A636V	SNU-1040	large_intestine	COSMIC	VVSTPTPS	DEG_SCF_FBW7_1	0.0556
p.C612Y	TCGA-AJ-A3OJ	UCEC	TCGA	VVSTPTPS	DEG_SCF_FBW7_1	0.1389
p.C612Y	TCGA-BK-A13B	UCEC	TCGA	VVSTPTPS	DEG_SCF_FBW7_1	0.1389
p.A632V	TCGA-AP-A05H	UCEC	TCGA	VVSTPTPS	DEG_SCF_FBW7_1	0.1667
p.C612F	TCGA-DX-A6YS	SARC	TCGA	VVSTPTPS	DEG_SCF_FBW7_1	0.1389
p.D617Y	TCGA-MP-A4TK	LUAD	TCGA	VVSTPTPS	DEG_SCF_FBW7_1	0.2778
p.A610S	DO229026	LICA	ICGC	VVSTPTPS	DEG_SCF_FBW7_1	0.0833
p.D611Y	DO26467	LUSC	ICGC	VVSTPTPS	DEG_SCF_FBW7_1	0.1111
p.L633F	DO52674	MALY	ICGC	VVSTPTPS	DEG_SCF_FBW7_1	0.1389
p.D609E	DO232071	ORCA	ICGC	VVSTPTPS	DEG_SCF_FBW7_1	0.0556
p.G616S	DO46818	RECA	ICGC	VVSTPTPS	DEG_SCF_FBW7_1	0.25
p.R615M	DO38404	STAD	ICGC	VVSTPTPS	DEG_SCF_FBW7_1	0.2222
p.T627I	DO41602	UCEC	ICGC	VVSTPTPS	DEG_SCF_FBW7_1	0.3056
p.L610Q	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	0.0833
p.L610Q	SIDM01181	Hepatocellular Carcinoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	0.0833
p.L610Q	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	0.0833
p.L610Q	SIDM01378	Ovarian Carcinoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	0.0833
p.V619L	SIDM00216	Colorectal Carcinoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	0.5654
p.V619L	ACH-000989	Colon/Colorectal Cancer	CCLE	VVSTPTPS	DEG_SCF_FBW7_1	0.5654
p.V619L	SNU-175	large_intestine	COSMIC	VVSTPTPS	DEG_SCF_FBW7_1	0.5654
p.V620I	SIDM00594	Acute Myeloid Leukemia	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	0.5965
p.V620I	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	0.5965
p.T622K	SIDM00656	Burkitt's Lymphoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	0.7306
p.T622K	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	0.7306
p.T622K	SIDM00641	Burkitt's Lymphoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	0.7306
p.E609K	SIDM00202	Ewing's Sarcoma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	0.0556
p.E609Q	SIDM00457	Plasma Cell Myeloma	GDSC	VVSTPTPS	DEG_SCF_FBW7_1	0.0556
p.E609Q	ACH-000024	Myeloma	CCLE	VVSTPTPS	DEG_SCF_FBW7_1	0.0556
p.E609Q	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VVSTPTPS	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVSTPTPS

Degron related mutations and impact score

Drug responses associated with SLITRK5 mutations

All proteins holding degron of VVSTPTPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94991	SLIT and NTRK-like protein 5	DEG_SCF_FBW7_1	619:626	VVSTPTPS	FBXW7	0.7671	More...