DegronMD

Uniprot ID: O94991

Source protein: SLIT and NTRK-like protein 5

Source gene: SLITRK5

Class: DEG_SPOP_SBC_1

Location: 316:320

E3 ligase: SPOP

DEGRON score: 0.5471

ASA_SCORE: 44.74

COIL: 0.7044

CONS_SCORE: 0.5142

DSS_SCORE: 0.5353

HELIX: 0.0556

FCONS_SCORE: 0.901

RIG_SCORE: 0.657

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P310Q	TCGA-43-2576	LUSC	TCGA	VATSS	DEG_SPOP_SBC_1	0.1667
p.T308N	TCGA-44-3918	LUAD	TCGA	VATSS	DEG_SPOP_SBC_1	0.1111
p.P310L	TCGA-D1-A167	UCEC	TCGA	VATSS	DEG_SPOP_SBC_1	0.1667
p.P310L	SIDM01560	Rhabdomyosarcoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.1667
p.S319Y	TCGA-EO-A22U	UCEC	TCGA	VATSS	DEG_SPOP_SBC_1	0.712
p.L306S	TCGA-EY-A214	UCEC	TCGA	VATSS	DEG_SPOP_SBC_1	0.0556
p.T318S	TCGA-MN-A4N4	LUAD	TCGA	VATSS	DEG_SPOP_SBC_1	0.6005
p.H307Y	TCGA-VS-A8EC	CESC	TCGA	VATSS	DEG_SPOP_SBC_1	0.0833
p.H307Y	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VATSS	DEG_SPOP_SBC_1	0.0833
p.H307Y	ACH-000937	Leukemia	CCLE	VATSS	DEG_SPOP_SBC_1	0.0833
p.H307Y	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	0.0833
p.D309E	DO233178	GACA	ICGC	VATSS	DEG_SPOP_SBC_1	0.1389
p.C326S	DO25058	LUAD	ICGC	VATSS	DEG_SPOP_SBC_1	0.1667
p.D318N	DO36556	READ	ICGC	VATSS	DEG_SPOP_SBC_1	0.6932
p.P323H	DO41361	UCEC	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.S320F	SIDM01175	Other Sarcomas	GDSC	VATSS	DEG_SPOP_SBC_1	0.7982
p.S320F	ACH-002309	Sarcoma	CCLE	VATSS	DEG_SPOP_SBC_1	0.7982
p.S320F	SW684	soft_tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	0.7982
p.T308I	SIDM00453	Pancreatic Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.1111
p.T308I	ACH-000023	Pancreatic Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	0.1111
p.T308I	PA-TU-8988T	pancreas	COSMIC	VATSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94991	SLIT and NTRK-like protein 5	DEG_SPOP_SBC_1	316:320	VATSS	SPOP	0.5471	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1761:1765	VATSS	SPOP	0.9537	More...
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	1557:1561	VATSS	SPOP	0.8877	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	971:975	VATSS	SPOP	0.9823	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	921:925	VATSS	SPOP	0.9219	More...
Q96CT7	Coiled-coil domain-containing protein 124	DEG_SPOP_SBC_1	89:93	VATSS	SPOP	0.9938	More...
Q9H1A4	Anaphase-promoting complex subunit 1	DEG_SPOP_SBC_1	295:299	VATSS	SPOP	0.8406	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	1484:1488	VATSS	SPOP	0.8289	More...
O43638	Forkhead box protein S1	DEG_SPOP_SBC_1	208:212	VATSS	SPOP	0.8893	More...
O75363	Breast carcinoma-amplified sequence 1	DEG_SPOP_SBC_1	59:63	VATSS	SPOP	0.9947	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	461:465	VATSS	SPOP	0.9974	More...
Q6UX68	XK-related protein 5	DEG_SPOP_SBC_1	550:554	VATSS	SPOP	0.9819	More...
Q9BTE0	Alpha/beta-tubulin-N-acetyltransferase 9	DEG_SPOP_SBC_1	164:168	VATSS	SPOP	0.7158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons