DegronMD

Uniprot ID: O75363

Source protein: Breast carcinoma-amplified sequence 1

Source gene: BCAS1

Class: DEG_SPOP_SBC_1

Location: 59:63

E3 ligase: SPOP

DEGRON score: 0.9947

ASA_SCORE: 86.4

COIL: 0.9662

CONS_SCORE: 0.8684

DSS_SCORE: 0.4619

HELIX: 0.0166

FCONS_SCORE: 1.2428

RIG_SCORE: 0.6985

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S53I	TCGA-28-2506	GBM	TCGA	VATSS	DEG_SPOP_SBC_1	0.1667
p.V54A	TCGA-A5-A0VP	UCEC	TCGA	VATSS	DEG_SPOP_SBC_1	0.1944
p.V54A	DO42600	UCEC	ICGC	VATSS	DEG_SPOP_SBC_1	0.1944
p.A73E	TCGA-BR-6801	STAD	TCGA	VATSS	DEG_SPOP_SBC_1	0.0556
p.A73E	DO228948	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	0.0556
p.A73E	DO38253	STAD	ICGC	VATSS	DEG_SPOP_SBC_1	0.0556
p.D49N	TCGA-CC-5259	LIHC	TCGA	VATSS	DEG_SPOP_SBC_1	0.0556
p.A73V	TCGA-CG-4442	STAD	TCGA	VATSS	DEG_SPOP_SBC_1	0.0556
p.A73V	DO228901	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	0.0556
p.A73V	DO38380	STAD	ICGC	VATSS	DEG_SPOP_SBC_1	0.0556
p.E65Q	TCGA-FD-A6TE	BLCA	TCGA	VATSS	DEG_SPOP_SBC_1	0.2778
p.E65Q	DO49759	BLCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.2778
p.T56S	DO508	BLCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.S70G	DO225346	BRCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.1389
p.V66A	DO228483	BRCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.V66A	DO230334	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.V66A	DO227709	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.V66A	DO229010	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.V66A	DO229013	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.V66A	DO229016	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.V66A	DO229003	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.V66A	DO229005	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.V66A	DO230659	LAML	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.V66A	DO231140	LAML	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.V66A	DO231141	LUSC	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.P61L	DO227984	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.7582
p.A60T	DO222755	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.6028
p.S63F	DO222671	ESCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.7982
p.H59Q	DO228902	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	0.7582
p.D52E	DO229041	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	0.1389
p.D64Y	DO23798	LUAD	ICGC	VATSS	DEG_SPOP_SBC_1	0.3056
p.Q63P	DO23798	LUAD	ICGC	VATSS	DEG_SPOP_SBC_1	0.7035
p.P49S	DO45312	LUAD	ICGC	VATSS	DEG_SPOP_SBC_1	0.0556
p.P49S	DO37406	SKCM	ICGC	VATSS	DEG_SPOP_SBC_1	0.0556
p.A62D	DO23976	LUAD	ICGC	VATSS	DEG_SPOP_SBC_1	0.7793
p.P73S	DO27018	LUSC	ICGC	VATSS	DEG_SPOP_SBC_1	0.0556
p.D52N	DO218861	SKCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.1389
p.D57N	DO218847	SKCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.2778
p.P49L	DO38795	STAD	ICGC	VATSS	DEG_SPOP_SBC_1	0.0556
p.D52Y	DO219777	UCEC	ICGC	VATSS	DEG_SPOP_SBC_1	0.1389
p.A62P	DO42113	UCEC	ICGC	VATSS	DEG_SPOP_SBC_1	0.7503
p.T56M	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.25
p.T56M	SIDM00690	Head and Neck Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.25
p.T56M	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.25
p.T56M	SIDM00628	Breast Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.25
p.T56M	SIDM01318	Hepatocellular Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.25
p.T56M	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.25
p.T56M	SIDM01752	Pancreatic Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.25
p.T56M	SIDM01525	Acute Myeloid Leukemia	GDSC	VATSS	DEG_SPOP_SBC_1	0.25
p.T67M	SIDM00032	Bladder Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.2222
p.L50F	ACH-000283	Brain Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	0.0833
p.L50F	ACH-000853	Lung Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	0.0833
p.L50F	NCI-H661	lung	COSMIC	VATSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94991	SLIT and NTRK-like protein 5	DEG_SPOP_SBC_1	316:320	VATSS	SPOP	0.5471	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1761:1765	VATSS	SPOP	0.9537	More...
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	1557:1561	VATSS	SPOP	0.8877	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	971:975	VATSS	SPOP	0.9823	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	921:925	VATSS	SPOP	0.9219	More...
Q96CT7	Coiled-coil domain-containing protein 124	DEG_SPOP_SBC_1	89:93	VATSS	SPOP	0.9938	More...
Q9H1A4	Anaphase-promoting complex subunit 1	DEG_SPOP_SBC_1	295:299	VATSS	SPOP	0.8406	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	1484:1488	VATSS	SPOP	0.8289	More...
O43638	Forkhead box protein S1	DEG_SPOP_SBC_1	208:212	VATSS	SPOP	0.8893	More...
O75363	Breast carcinoma-amplified sequence 1	DEG_SPOP_SBC_1	59:63	VATSS	SPOP	0.9947	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	461:465	VATSS	SPOP	0.9974	More...
Q6UX68	XK-related protein 5	DEG_SPOP_SBC_1	550:554	VATSS	SPOP	0.9819	More...
Q9BTE0	Alpha/beta-tubulin-N-acetyltransferase 9	DEG_SPOP_SBC_1	164:168	VATSS	SPOP	0.7158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VATSS

Degron related mutations and impact score

Drug responses associated with BCAS1 mutations

All proteins holding degron of VATSS