DegronMD - O43638(FOXS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P221T	TCGA-AG-A002	READ	TCGA	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0833
p.F224L	TCGA-AJ-A3EK	UCEC	TCGA	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.0556
p.F224L	TCGA-QF-A5YS	UCEC	TCGA	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.0556
p.F224L	DO41584	UCEC	ICGC	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.0556
p.F224L	DO52426	UCEC	ICGC	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.0556
p.V208M	TCGA-AJ-A8CT	UCEC	TCGA	VATSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.7208
p.V208M	DO52399	UCEC	ICGC	VATSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.7208
p.P221S	TCGA-D3-A8GI	SKCM	TCGA	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0833
p.P221S	DO50284	SKCM	ICGC	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0833
p.S271L	TCGA-D9-A1JX	SKCM	TCGA	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.1389
p.S271L	DO37711	SKCM	ICGC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.1389
p.E205K	TCGA-DK-A1AC	BLCA	TCGA	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.25
p.E205K	DO514	BLCA	ICGC	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.25
p.G245E	TCGA-DU-6407	LGG	TCGA	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.1667
p.G245E	DO22295	LGG	ICGC	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.1667
p.P274S	TCGA-EE-A29H	SKCM	TCGA	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.2222
p.P274S	DO37535	SKCM	ICGC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.2222
p.G204V	TCGA-EE-A2GN	SKCM	TCGA	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.2222
p.G204V	DO37896	SKCM	ICGC	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.2222
p.S214L	TCGA-EE-A2MU	SKCM	TCGA	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.2778
p.S214L	DO37436	SKCM	ICGC	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.2778
p.A222V	TCGA-EY-A1GK	UCEC	TCGA	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0556
p.A222V	DO42985	UCEC	ICGC	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0556
p.P276S	TCGA-FR-A726	SKCM	TCGA	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.2778
p.P276S	DO48665	SKCM	ICGC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.2778
p.R286L	TCGA-FS-A1ZA	SKCM	TCGA	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.2778
p.R286L	DO37551	SKCM	ICGC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.2778
p.A217E	TCGA-XD-AAUG	PAAD	TCGA	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1944
p.A217E	DO51720	PAAD	ICGC	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1944
p.T235M	DO227692	COCA	ICGC	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation altering degron motif	0.7423
p.T235M	SIDM00151	Ovarian Carcinoma	GDSC	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation altering degron motif	0.7423
p.T235M	ACH-000966	Ovarian Cancer	CCLE	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation altering degron motif	0.7423
p.T235M	IGROV-1	ovary	COSMIC	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation altering degron motif	0.7423
p.F230C	DO222762	COCA	ICGC	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.2222
p.P282Q	DO233843	GACA	ICGC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation altering degron motif	0.5924
p.V237F	DO228562	LICA	ICGC	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation altering degron motif	0.5957
p.V237F	DO228807	LICA	ICGC	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation altering degron motif	0.5957
p.P288Q	DO228974	LICA	ICGC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.2222
p.A233D	DO229015	LICA	ICGC	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.3056
p.A233D	DO229037	LICA	ICGC	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.3056
p.E226K	DO222395	MELA	ICGC	PTPVLS	DEG_SCF_FBW7_1	234:239	Mutation rewiring degron network	0.1111
p.P281S	DO222550	MELA	ICGC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation altering degron motif	0.6752
p.T280P	DO48573	PAEN	ICGC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation altering degron motif	0.7031
p.R286Q	SIDM02059	Colorectal Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.2778
p.R286Q	SIDM00491	Thyroid Gland Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.2778
p.R286Q	ASH-3	thyroid	COSMIC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.2778
p.A287D	SIDM00334	Endometrial Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.25
p.A287D	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.25
p.P292A	SIDM00234	Other Solid Cancers	GDSC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.1111
p.P292A	SIDM00614	Hepatocellular Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.1111
p.P292A	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.1111
p.P292A	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.1111
p.P292A	SIDM01343	Gastric Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	278:284	Mutation rewiring degron network	0.1111
p.A217V	SIDM00217	Colorectal Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1944
p.A217V	ACH-000999	Colon/Colorectal Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1944
p.A217V	SNU-1040	large intestine	COSMIC	VATSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXS1

UniProt ID: O43638

Entrez ID: 2307

Protein name: Forkhead box protein S1 (Forkhead-like 18 protein) (Forkhead-related transcription factor 10) (FREAC-10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXS1 in