DegronMD

Uniprot ID: O43638

Source protein: Forkhead box protein S1

Source gene: FOXS1

Class: DEG_SCF_FBW7_1

Location: 278:284

E3 ligase: FBXW7

DEGRON score: 0.9532

ASA_SCORE: 77.1

COIL: 0.9509

CONS_SCORE: 0.6029

DSS_SCORE: 0.6419

HELIX: 0.0276

FCONS_SCORE: 1.02

RIG_SCORE: 0.549

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S271L	TCGA-D9-A1JX	SKCM	TCGA	PPTPPGS	DEG_SCF_FBW7_1	0.1389
p.S271L	DO37711	SKCM	ICGC	PPTPPGS	DEG_SCF_FBW7_1	0.1389
p.P274S	TCGA-EE-A29H	SKCM	TCGA	PPTPPGS	DEG_SCF_FBW7_1	0.2222
p.P274S	DO37535	SKCM	ICGC	PPTPPGS	DEG_SCF_FBW7_1	0.2222
p.P276S	TCGA-FR-A726	SKCM	TCGA	PPTPPGS	DEG_SCF_FBW7_1	0.2778
p.P276S	DO48665	SKCM	ICGC	PPTPPGS	DEG_SCF_FBW7_1	0.2778
p.R286L	TCGA-FS-A1ZA	SKCM	TCGA	PPTPPGS	DEG_SCF_FBW7_1	0.2778
p.R286L	DO37551	SKCM	ICGC	PPTPPGS	DEG_SCF_FBW7_1	0.2778
p.P282Q	DO233843	GACA	ICGC	PPTPPGS	DEG_SCF_FBW7_1	0.5924
p.P288Q	DO228974	LICA	ICGC	PPTPPGS	DEG_SCF_FBW7_1	0.2222
p.P281S	DO222550	MELA	ICGC	PPTPPGS	DEG_SCF_FBW7_1	0.6752
p.T280P	DO48573	PAEN	ICGC	PPTPPGS	DEG_SCF_FBW7_1	0.7031
p.R286Q	SIDM02059	Colorectal Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	0.2778
p.R286Q	SIDM00491	Thyroid Gland Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	0.2778
p.R286Q	ASH-3	thyroid	COSMIC	PPTPPGS	DEG_SCF_FBW7_1	0.2778
p.A287D	SIDM00334	Endometrial Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	0.25
p.A287D	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	0.25
p.P292A	SIDM00234	Other Solid Cancers	GDSC	PPTPPGS	DEG_SCF_FBW7_1	0.1111
p.P292A	SIDM00614	Hepatocellular Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	0.1111
p.P292A	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	0.1111
p.P292A	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	0.1111
p.P292A	SIDM01343	Gastric Carcinoma	GDSC	PPTPPGS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43638	Forkhead box protein S1	DEG_SCF_FBW7_1	278:284	PPTPPGS	FBXW7	0.9532	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons