DegronMD

Uniprot ID: O43638

Source protein: Forkhead box protein S1

Source gene: FOXS1

Class: DEG_SPOP_SBC_1

Location: 208:212

E3 ligase: SPOP

DEGRON score: 0.8893

ASA_SCORE: 64.42

COIL: 0.8818

CONS_SCORE: 0.5898

DSS_SCORE: 0.3791

HELIX: 0.0592

FCONS_SCORE: 1.0043

RIG_SCORE: 0.6708

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P221T	TCGA-AG-A002	READ	TCGA	VATSS	DEG_SPOP_SBC_1	0.0833
p.V208M	TCGA-AJ-A8CT	UCEC	TCGA	VATSS	DEG_SPOP_SBC_1	0.7208
p.V208M	DO52399	UCEC	ICGC	VATSS	DEG_SPOP_SBC_1	0.7208
p.P221S	TCGA-D3-A8GI	SKCM	TCGA	VATSS	DEG_SPOP_SBC_1	0.0833
p.P221S	DO50284	SKCM	ICGC	VATSS	DEG_SPOP_SBC_1	0.0833
p.E205K	TCGA-DK-A1AC	BLCA	TCGA	VATSS	DEG_SPOP_SBC_1	0.25
p.E205K	DO514	BLCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.G204V	TCGA-EE-A2GN	SKCM	TCGA	VATSS	DEG_SPOP_SBC_1	0.2222
p.G204V	DO37896	SKCM	ICGC	VATSS	DEG_SPOP_SBC_1	0.2222
p.S214L	TCGA-EE-A2MU	SKCM	TCGA	VATSS	DEG_SPOP_SBC_1	0.2778
p.S214L	DO37436	SKCM	ICGC	VATSS	DEG_SPOP_SBC_1	0.2778
p.A222V	TCGA-EY-A1GK	UCEC	TCGA	VATSS	DEG_SPOP_SBC_1	0.0556
p.A222V	DO42985	UCEC	ICGC	VATSS	DEG_SPOP_SBC_1	0.0556
p.A217E	TCGA-XD-AAUG	PAAD	TCGA	VATSS	DEG_SPOP_SBC_1	0.1944
p.A217E	DO51720	PAAD	ICGC	VATSS	DEG_SPOP_SBC_1	0.1944
p.A217V	SIDM00217	Colorectal Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.1944
p.A217V	ACH-000999	Colon/Colorectal Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	0.1944
p.A217V	SNU-1040	large_intestine	COSMIC	VATSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94991	SLIT and NTRK-like protein 5	DEG_SPOP_SBC_1	316:320	VATSS	SPOP	0.5471	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1761:1765	VATSS	SPOP	0.9537	More...
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	1557:1561	VATSS	SPOP	0.8877	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	971:975	VATSS	SPOP	0.9823	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	921:925	VATSS	SPOP	0.9219	More...
Q96CT7	Coiled-coil domain-containing protein 124	DEG_SPOP_SBC_1	89:93	VATSS	SPOP	0.9938	More...
Q9H1A4	Anaphase-promoting complex subunit 1	DEG_SPOP_SBC_1	295:299	VATSS	SPOP	0.8406	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	1484:1488	VATSS	SPOP	0.8289	More...
O43638	Forkhead box protein S1	DEG_SPOP_SBC_1	208:212	VATSS	SPOP	0.8893	More...
O75363	Breast carcinoma-amplified sequence 1	DEG_SPOP_SBC_1	59:63	VATSS	SPOP	0.9947	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	461:465	VATSS	SPOP	0.9974	More...
Q6UX68	XK-related protein 5	DEG_SPOP_SBC_1	550:554	VATSS	SPOP	0.9819	More...
Q9BTE0	Alpha/beta-tubulin-N-acetyltransferase 9	DEG_SPOP_SBC_1	164:168	VATSS	SPOP	0.7158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons