DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VATSS
Uniprot ID:
E9PAV3
Source protein:
Nascent polypeptide-associated complex subunit alpha, muscle-specific form
Source gene:
NACA
Class:
DEG_SPOP_SBC_1
Location:
1484:1488
E3 ligase:
SPOP
DEGRON score:
0.8289
ASA_SCORE:
85.6
COIL:
0.945
CONS_SCORE:
0.1705
DSS_SCORE:
0.7343
HELIX:
0.0184
FCONS_SCORE:
0.5277
RIG_SCORE:
0.5787
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A1498S
DO26806
LUSC
ICGC
VATSS
DEG_SPOP_SBC_1
0.0556
p.P1478H
DO48175
UCEC
ICGC
VATSS
DEG_SPOP_SBC_1
0.1667
Drug responses associated with NACA mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VATSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94991
SLIT and NTRK-like protein 5
DEG_SPOP_SBC_1
316:320
VATSS
SPOP
0.5471
More...
P13611
Versican core protein
DEG_SPOP_SBC_1
1761:1765
VATSS
SPOP
0.9537
More...
P46821
Microtubule-associated protein 1B
DEG_SPOP_SBC_1
1557:1561
VATSS
SPOP
0.8877
More...
P49750
YLP motif-containing protein 1
DEG_SPOP_SBC_1
971:975
VATSS
SPOP
0.9823
More...
Q03164
Histone-lysine N-methyltransferase 2A
DEG_SPOP_SBC_1
921:925
VATSS
SPOP
0.9219
More...
Q96CT7
Coiled-coil domain-containing protein 124
DEG_SPOP_SBC_1
89:93
VATSS
SPOP
0.9938
More...
Q9H1A4
Anaphase-promoting complex subunit 1
DEG_SPOP_SBC_1
295:299
VATSS
SPOP
0.8406
More...
E9PAV3
Nascent polypeptide-associated complex subunit alpha, muscle-specific form
DEG_SPOP_SBC_1
1484:1488
VATSS
SPOP
0.8289
More...
O43638
Forkhead box protein S1
DEG_SPOP_SBC_1
208:212
VATSS
SPOP
0.8893
More...
O75363
Breast carcinoma-amplified sequence 1
DEG_SPOP_SBC_1
59:63
VATSS
SPOP
0.9947
More...
Q96KR1
Zinc finger RNA-binding protein
DEG_SPOP_SBC_1
461:465
VATSS
SPOP
0.9974
More...
Q6UX68
XK-related protein 5
DEG_SPOP_SBC_1
550:554
VATSS
SPOP
0.9819
More...
Q9BTE0
Alpha/beta-tubulin-N-acetyltransferase 9
DEG_SPOP_SBC_1
164:168
VATSS
SPOP
0.7158
More...