DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: DEG_SPOP_SBC_1

Location: 1761:1765

E3 ligase: SPOP

DEGRON score: 0.9537

ASA_SCORE: 77.34

COIL: 0.775

CONS_SCORE: 0.3935

DSS_SCORE: 0.5489

HELIX: 0.023

FCONS_SCORE: 0.9295

RIG_SCORE: 0.6441

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1767T	TCGA-14-1458	GBM	TCGA	VATSS	DEG_SPOP_SBC_1	0.2778
p.S1767T	DO13851	GBM	ICGC	VATSS	DEG_SPOP_SBC_1	0.2778
p.F1754I	TCGA-17-Z022	LUAD	TCGA	VATSS	DEG_SPOP_SBC_1	0.1389
p.T1763A	TCGA-AA-A010	COAD	TCGA	VATSS	DEG_SPOP_SBC_1	0.7139
p.D1766E	TCGA-DU-6392	LGG	TCGA	VATSS	DEG_SPOP_SBC_1	0.3056
p.D1766E	DO22237	LGG	ICGC	VATSS	DEG_SPOP_SBC_1	0.3056
p.F1773V	TCGA-F5-6814	READ	TCGA	VATSS	DEG_SPOP_SBC_1	0.1111
p.F1773V	DO36556	READ	ICGC	VATSS	DEG_SPOP_SBC_1	0.1111
p.P1753S	TCGA-GF-A6C9	SKCM	TCGA	VATSS	DEG_SPOP_SBC_1	0.1111
p.P1753S	DO51254	SKCM	ICGC	VATSS	DEG_SPOP_SBC_1	0.1111
p.A1762S	DO228971	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	0.6477
p.F1773C	DO220857	MELA	ICGC	VATSS	DEG_SPOP_SBC_1	0.1111
p.F1773S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VATSS	DEG_SPOP_SBC_1	0.1111
p.F1773S	ACH-002256	Leukemia	CCLE	VATSS	DEG_SPOP_SBC_1	0.1111
p.F1773S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	0.1111
p.S1758G	SIDM00564	Ovarian Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.25
p.S1758G	ACH-000527	Ovarian Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	0.25
p.S1758G	OVISE	ovary	COSMIC	VATSS	DEG_SPOP_SBC_1	0.25
p.G1768D	SIDM00836	Colorectal Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.25
p.G1768D	ACH-000820	Colon/Colorectal Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	0.25
p.G1768D	SW403	large_intestine	COSMIC	VATSS	DEG_SPOP_SBC_1	0.25
p.I1751M	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	0.0556
p.A1770T	NCI-H1155	lung	COSMIC	VATSS	DEG_SPOP_SBC_1	0.1944
p.E1758K	HT-1376	urinary_tract	COSMIC	VATSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94991	SLIT and NTRK-like protein 5	DEG_SPOP_SBC_1	316:320	VATSS	SPOP	0.5471	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1761:1765	VATSS	SPOP	0.9537	More...
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	1557:1561	VATSS	SPOP	0.8877	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	971:975	VATSS	SPOP	0.9823	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	921:925	VATSS	SPOP	0.9219	More...
Q96CT7	Coiled-coil domain-containing protein 124	DEG_SPOP_SBC_1	89:93	VATSS	SPOP	0.9938	More...
Q9H1A4	Anaphase-promoting complex subunit 1	DEG_SPOP_SBC_1	295:299	VATSS	SPOP	0.8406	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	1484:1488	VATSS	SPOP	0.8289	More...
O43638	Forkhead box protein S1	DEG_SPOP_SBC_1	208:212	VATSS	SPOP	0.8893	More...
O75363	Breast carcinoma-amplified sequence 1	DEG_SPOP_SBC_1	59:63	VATSS	SPOP	0.9947	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	461:465	VATSS	SPOP	0.9974	More...
Q6UX68	XK-related protein 5	DEG_SPOP_SBC_1	550:554	VATSS	SPOP	0.9819	More...
Q9BTE0	Alpha/beta-tubulin-N-acetyltransferase 9	DEG_SPOP_SBC_1	164:168	VATSS	SPOP	0.7158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons