DegronMD - Q9H1A4(ANAPC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S386Y	TCGA-AJ-A3EL	UCEC	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation blocking phosphorylation signal	0.5
p.S386Y	DO41542	UCEC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation blocking phosphorylation signal	0.5
p.D410A	TCGA-AX-A06F	UCEC	TCGA	ETEPIVPEL	DEG_COP1_1	399:407	Mutation rewiring degron network	0.25
p.D410A	TCGA-AX-A06F	UCEC	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.3056
p.D410A	DO41752	UCEC	ICGC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation rewiring degron network	0.25
p.D410A	DO41752	UCEC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.3056
p.L396I	TCGA-AX-A2HC	UCEC	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation altering degron motif	0.6063
p.L396I	DO41572	UCEC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation altering degron motif	0.6063
p.S286Y	TCGA-BB-4225	HNSC	TCGA	VATSS	DEG_SPOP_SBC_1	295:299	Mutation blocking phosphorylation signal	0.5278
p.S286Y	DO14264	HNSC	ICGC	VATSS	DEG_SPOP_SBC_1	295:299	Mutation blocking phosphorylation signal	0.5278
p.T400M	TCGA-BR-8078	STAD	TCGA	ETEPIVPEL	DEG_COP1_1	399:407	Mutation altering degron motif	0.6312
p.T400M	TCGA-BR-8078	STAD	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation altering degron motif	0.6312
p.T400M	DO38288	STAD	ICGC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation altering degron motif	0.6312
p.T400M	DO38288	STAD	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation altering degron motif	0.6312
p.T400M	SIDM00132	Pancreatic Carcinoma	GDSC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation altering degron motif	0.6312
p.T400M	SIDM00132	Pancreatic Carcinoma	GDSC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation altering degron motif	0.6312
p.T400M	BxPC-3	pancreas	COSMIC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation altering degron motif	0.6312
p.T400M	BxPC-3	pancreas	COSMIC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation altering degron motif	0.6312
p.S391A	TCGA-D1-A103	UCEC	TCGA	ETEPIVPEL	DEG_COP1_1	399:407	Mutation rewiring degron network	0.1111
p.S391A	TCGA-D1-A103	UCEC	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.1944
p.S391A	DO42312	UCEC	ICGC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation rewiring degron network	0.1111
p.S391A	DO42312	UCEC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.1944
p.P387Q	TCGA-EE-A29L	SKCM	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.0833
p.P387Q	DO37835	SKCM	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.0833
p.N392D	TCGA-EJ-7125	PRAD	TCGA	ETEPIVPEL	DEG_COP1_1	399:407	Mutation rewiring degron network	0.1389
p.N392D	TCGA-EJ-7125	PRAD	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.2222
p.N392D	DO36326	PRAD	ICGC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation rewiring degron network	0.1389
p.N392D	DO36326	PRAD	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.2222
p.E401K	TCGA-QB-AA9O	SKCM	TCGA	ETEPIVPEL	DEG_COP1_1	399:407	Mutation altering degron motif	0.591
p.E401K	TCGA-QB-AA9O	SKCM	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation altering degron motif	0.591
p.E401K	DO51267	SKCM	ICGC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation altering degron motif	0.591
p.E401K	DO51267	SKCM	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation altering degron motif	0.591
p.E401K	SIDM01175	Other Sarcomas	GDSC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation altering degron motif	0.591
p.E401K	SIDM01175	Other Sarcomas	GDSC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation altering degron motif	0.591
p.E401K	ACH-002309	Sarcoma	CCLE	ETEPIVPEL	DEG_COP1_1	399:407	Mutation altering degron motif	0.591
p.E401K	ACH-002309	Sarcoma	CCLE	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation altering degron motif	0.591
p.E401K	SW684	soft tissue	COSMIC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation altering degron motif	0.591
p.E401K	SW684	soft tissue	COSMIC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation altering degron motif	0.591
p.C408Y	TCGA-VD-A8KI	UVM	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation altering degron motif	0.5976
p.P387L	TCGA-WE-A8ZT	SKCM	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.0833
p.P387L	DO51290	SKCM	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.0833
p.T416M	DO48452	BLCA	ICGC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation rewiring degron network	0.0833
p.T416M	DO48452	BLCA	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.1389
p.T416M	DO229005	COCA	ICGC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation rewiring degron network	0.0833
p.T416M	DO229005	COCA	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.1389
p.T416M	DO50988	LAML	ICGC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation rewiring degron network	0.0833
p.T416M	DO50988	LAML	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.1389
p.T416M	DO52364	LUSC	ICGC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation rewiring degron network	0.0833
p.T416M	DO52364	LUSC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.1389
p.T416M	DO52367	LUSC	ICGC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation rewiring degron network	0.0833
p.T416M	DO52367	LUSC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.1389
p.T416M	DO52354	LUSC	ICGC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation rewiring degron network	0.0833
p.T416M	DO52354	LUSC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.1389
p.T416M	DO52388	LUSC	ICGC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation rewiring degron network	0.0833
p.T416M	DO52388	LUSC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.1389
p.Q288H	DO234199	ESAD	ICGC	VATSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1389
p.T302A	DO228522	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.25
p.A397E	DO229024	LICA	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation altering degron motif	0.7701
p.T297A	SIDM00150	Colorectal Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	295:299	Mutation altering degron motif	0.7139
p.T297A	ACH-000969	Colon/Colorectal Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	295:299	Mutation altering degron motif	0.7139
p.T297A	KM12	large intestine	COSMIC	VATSS	DEG_SPOP_SBC_1	295:299	Mutation altering degron motif	0.7139
p.H411R	SIDM01323	Oral Cavity Carcinoma	GDSC	ETEPIVPEL	DEG_COP1_1	399:407	Mutation rewiring degron network	0.2222
p.H411R	SIDM01323	Oral Cavity Carcinoma	GDSC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.2778
p.H411R	ACH-000732	Head and Neck Cancer	CCLE	ETEPIVPEL	DEG_COP1_1	399:407	Mutation rewiring degron network	0.2222
p.H411R	ACH-000732	Head and Neck Cancer	CCLE	LAPETEPIVPELCI	DEG_ODPH_VHL_1	396:409	Mutation rewiring degron network	0.2778
p.T291P	ACH-000914	Lymphoma	CCLE	VATSS	DEG_SPOP_SBC_1	295:299	Mutation blocking phosphorylation signal	0.6667
p.T291P	HT	haematopoietic and lymphoid tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	295:299	Mutation blocking phosphorylation signal	0.6667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANAPC1

UniProt ID: Q9H1A4

Entrez ID: 64682

Protein name: Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANAPC1 in