DegronMD

Uniprot ID: Q9H1A4

Source protein: Anaphase-promoting complex subunit 1

Source gene: ANAPC1

Class: DEG_COP1_1

Location: 399:407

E3 ligase: COP1

DEGRON score: 0.9906

ASA_SCORE: 70.3778

COIL: 0.8014

CONS_SCORE: 0.2996

DSS_SCORE: 0.3516

HELIX: 0.0452

FCONS_SCORE: 1.1197

RIG_SCORE: 0.7801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D410A	TCGA-AX-A06F	UCEC	TCGA	ETEPIVPEL	DEG_COP1_1	0.25
p.D410A	DO41752	UCEC	ICGC	ETEPIVPEL	DEG_COP1_1	0.25
p.T400M	TCGA-BR-8078	STAD	TCGA	ETEPIVPEL	DEG_COP1_1	0.6312
p.T400M	DO38288	STAD	ICGC	ETEPIVPEL	DEG_COP1_1	0.6312
p.T400M	SIDM00132	Pancreatic Carcinoma	GDSC	ETEPIVPEL	DEG_COP1_1	0.6312
p.T400M	BxPC-3	pancreas	COSMIC	ETEPIVPEL	DEG_COP1_1	0.6312
p.S391A	TCGA-D1-A103	UCEC	TCGA	ETEPIVPEL	DEG_COP1_1	0.1111
p.S391A	DO42312	UCEC	ICGC	ETEPIVPEL	DEG_COP1_1	0.1111
p.N392D	TCGA-EJ-7125	PRAD	TCGA	ETEPIVPEL	DEG_COP1_1	0.1389
p.N392D	DO36326	PRAD	ICGC	ETEPIVPEL	DEG_COP1_1	0.1389
p.E401K	TCGA-QB-AA9O	SKCM	TCGA	ETEPIVPEL	DEG_COP1_1	0.591
p.E401K	DO51267	SKCM	ICGC	ETEPIVPEL	DEG_COP1_1	0.591
p.E401K	SIDM01175	Other Sarcomas	GDSC	ETEPIVPEL	DEG_COP1_1	0.591
p.E401K	ACH-002309	Sarcoma	CCLE	ETEPIVPEL	DEG_COP1_1	0.591
p.E401K	SW684	soft_tissue	COSMIC	ETEPIVPEL	DEG_COP1_1	0.591
p.T416M	DO48452	BLCA	ICGC	ETEPIVPEL	DEG_COP1_1	0.0833
p.T416M	DO229005	COCA	ICGC	ETEPIVPEL	DEG_COP1_1	0.0833
p.T416M	DO50988	LAML	ICGC	ETEPIVPEL	DEG_COP1_1	0.0833
p.T416M	DO52364	LUSC	ICGC	ETEPIVPEL	DEG_COP1_1	0.0833
p.T416M	DO52367	LUSC	ICGC	ETEPIVPEL	DEG_COP1_1	0.0833
p.T416M	DO52354	LUSC	ICGC	ETEPIVPEL	DEG_COP1_1	0.0833
p.T416M	DO52388	LUSC	ICGC	ETEPIVPEL	DEG_COP1_1	0.0833
p.H411R	SIDM01323	Oral Cavity Carcinoma	GDSC	ETEPIVPEL	DEG_COP1_1	0.2222
p.H411R	ACH-000732	Head and Neck Cancer	CCLE	ETEPIVPEL	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H1A4	Anaphase-promoting complex subunit 1	DEG_COP1_1	399:407	ETEPIVPEL	COP1	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons