DegronMD

Uniprot ID: Q9H1A4

Source protein: Anaphase-promoting complex subunit 1

Source gene: ANAPC1

Class: DEG_ODPH_VHL_1

Location: 396:409

E3 ligase: VHL

DEGRON score: 0.9787

ASA_SCORE: 60.5857

COIL: 0.7079

CONS_SCORE: 0.2922

DSS_SCORE: 0.3889

HELIX: 0.0564

FCONS_SCORE: 1.1462

RIG_SCORE: 0.7739

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S386Y	TCGA-AJ-A3EL	UCEC	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.5
p.S386Y	DO41542	UCEC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.5
p.D410A	TCGA-AX-A06F	UCEC	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.3056
p.D410A	DO41752	UCEC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.3056
p.L396I	TCGA-AX-A2HC	UCEC	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.6063
p.L396I	DO41572	UCEC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.6063
p.T400M	TCGA-BR-8078	STAD	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.6312
p.T400M	DO38288	STAD	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.6312
p.T400M	SIDM00132	Pancreatic Carcinoma	GDSC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.6312
p.T400M	BxPC-3	pancreas	COSMIC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.6312
p.S391A	TCGA-D1-A103	UCEC	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.1944
p.S391A	DO42312	UCEC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.1944
p.P387Q	TCGA-EE-A29L	SKCM	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.0833
p.P387Q	DO37835	SKCM	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.0833
p.N392D	TCGA-EJ-7125	PRAD	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.2222
p.N392D	DO36326	PRAD	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.2222
p.E401K	TCGA-QB-AA9O	SKCM	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.591
p.E401K	DO51267	SKCM	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.591
p.E401K	SIDM01175	Other Sarcomas	GDSC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.591
p.E401K	ACH-002309	Sarcoma	CCLE	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.591
p.E401K	SW684	soft_tissue	COSMIC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.591
p.C408Y	TCGA-VD-A8KI	UVM	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.5976
p.P387L	TCGA-WE-A8ZT	SKCM	TCGA	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.0833
p.P387L	DO51290	SKCM	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.0833
p.T416M	DO48452	BLCA	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.1389
p.T416M	DO229005	COCA	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.1389
p.T416M	DO50988	LAML	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.1389
p.T416M	DO52364	LUSC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.1389
p.T416M	DO52367	LUSC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.1389
p.T416M	DO52354	LUSC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.1389
p.T416M	DO52388	LUSC	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.1389
p.A397E	DO229024	LICA	ICGC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.7701
p.H411R	SIDM01323	Oral Cavity Carcinoma	GDSC	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.2778
p.H411R	ACH-000732	Head and Neck Cancer	CCLE	LAPETEPIVPELCI	DEG_ODPH_VHL_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPETEPIVPELCI

Degron related mutations and impact score

Drug responses associated with ANAPC1 mutations

All proteins holding degron of LAPETEPIVPELCI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H1A4	Anaphase-promoting complex subunit 1	DEG_ODPH_VHL_1	396:409	LAPETEPIVPELCI	VHL	0.9787	More...