DegronMD

Uniprot ID: Q9H1A4

Source protein: Anaphase-promoting complex subunit 1

Source gene: ANAPC1

Class: DEG_SPOP_SBC_1

Location: 295:299

E3 ligase: SPOP

DEGRON score: 0.8406

ASA_SCORE: 62.62

COIL: 0.6764

CONS_SCORE: 0.2261

DSS_SCORE: 0.539

HELIX: 0.2658

FCONS_SCORE: 0.9802

RIG_SCORE: 0.6966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S286Y	TCGA-BB-4225	HNSC	TCGA	VATSS	DEG_SPOP_SBC_1	0.5278
p.S286Y	DO14264	HNSC	ICGC	VATSS	DEG_SPOP_SBC_1	0.5278
p.Q288H	DO234199	ESAD	ICGC	VATSS	DEG_SPOP_SBC_1	0.1389
p.T302A	DO228522	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.T297A	SIDM00150	Colorectal Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.7139
p.T297A	ACH-000969	Colon/Colorectal Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	0.7139
p.T297A	KM12	large_intestine	COSMIC	VATSS	DEG_SPOP_SBC_1	0.7139
p.T291P	ACH-000914	Lymphoma	CCLE	VATSS	DEG_SPOP_SBC_1	0.6667
p.T291P	HT	haematopoietic_and_lymphoid_tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94991	SLIT and NTRK-like protein 5	DEG_SPOP_SBC_1	316:320	VATSS	SPOP	0.5471	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1761:1765	VATSS	SPOP	0.9537	More...
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	1557:1561	VATSS	SPOP	0.8877	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	971:975	VATSS	SPOP	0.9823	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	921:925	VATSS	SPOP	0.9219	More...
Q96CT7	Coiled-coil domain-containing protein 124	DEG_SPOP_SBC_1	89:93	VATSS	SPOP	0.9938	More...
Q9H1A4	Anaphase-promoting complex subunit 1	DEG_SPOP_SBC_1	295:299	VATSS	SPOP	0.8406	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	1484:1488	VATSS	SPOP	0.8289	More...
O43638	Forkhead box protein S1	DEG_SPOP_SBC_1	208:212	VATSS	SPOP	0.8893	More...
O75363	Breast carcinoma-amplified sequence 1	DEG_SPOP_SBC_1	59:63	VATSS	SPOP	0.9947	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	461:465	VATSS	SPOP	0.9974	More...
Q6UX68	XK-related protein 5	DEG_SPOP_SBC_1	550:554	VATSS	SPOP	0.9819	More...
Q9BTE0	Alpha/beta-tubulin-N-acetyltransferase 9	DEG_SPOP_SBC_1	164:168	VATSS	SPOP	0.7158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons