DegronMD - O75363(BCAS1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S386L	TCGA-12-3646	GBM	TCGA	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation altering degron motif	0.7667
p.S386L	DO12184	GBM	ICGC	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation altering degron motif	0.7667
p.S53I	TCGA-28-2506	GBM	TCGA	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1667
p.E393D	TCGA-30-1853	OV	TCGA	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation rewiring degron network	0.2778
p.E393D	DO28002	OV	ICGC	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation rewiring degron network	0.2778
p.E393D	SIDM00425	Ovarian Carcinoma	GDSC	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation rewiring degron network	0.2778
p.E393D	ACH-000663	Ovarian Cancer	CCLE	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation rewiring degron network	0.2778
p.E393D	OVTOKO	ovary	COSMIC	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation rewiring degron network	0.2778
p.D385H	TCGA-44-2656	LUAD	TCGA	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation altering degron motif	0.6577
p.D385H	DO26052	LUAD	ICGC	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation altering degron motif	0.6577
p.V54A	TCGA-A5-A0VP	UCEC	TCGA	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1944
p.V54A	DO42600	UCEC	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1944
p.S399P	TCGA-A7-A0D9	BRCA	TCGA	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation blocking phosphorylation signal	0.5556
p.S399P	DO4128	BRCA	ICGC	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation blocking phosphorylation signal	0.5556
p.A73E	TCGA-BR-6801	STAD	TCGA	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0556
p.A73E	DO228948	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0556
p.A73E	DO38253	STAD	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0556
p.D49N	TCGA-CC-5259	LIHC	TCGA	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0556
p.A73V	TCGA-CG-4442	STAD	TCGA	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0556
p.A73V	DO228901	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0556
p.A73V	DO38380	STAD	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0556
p.E65Q	TCGA-FD-A6TE	BLCA	TCGA	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.2778
p.E65Q	DO49759	BLCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.2778
p.E392K	TCGA-FS-A1ZC	SKCM	TCGA	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation rewiring degron network	0.3056
p.E392K	TCGA-FW-A3R5	SKCM	TCGA	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation rewiring degron network	0.3056
p.E392K	DO37406	SKCM	ICGC	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation rewiring degron network	0.3056
p.E392K	DO37487	SKCM	ICGC	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation rewiring degron network	0.3056
p.T56S	DO508	BLCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.S70G	DO225346	BRCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1389
p.V66A	DO228483	BRCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.V66A	DO230334	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.V66A	DO227709	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.V66A	DO229010	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.V66A	DO229013	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.V66A	DO229016	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.V66A	DO229003	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.V66A	DO229005	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.V66A	DO230659	LAML	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.V66A	DO231140	LAML	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.V66A	DO231141	LUSC	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.P61L	DO227984	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation altering degron motif	0.7582
p.A60T	DO222755	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation altering degron motif	0.6028
p.S63F	DO222671	ESCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation altering degron motif	0.7982
p.H59Q	DO228902	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation altering degron motif	0.7582
p.D52E	DO229041	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1389
p.D64Y	DO23798	LUAD	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.3056
p.Q63P	DO23798	LUAD	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation altering degron motif	0.7035
p.P49S	DO45312	LUAD	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0556
p.P49S	DO37406	SKCM	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0556
p.A62D	DO23976	LUAD	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation altering degron motif	0.7793
p.P73S	DO27018	LUSC	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0556
p.K380R	DO33091	PACA	ICGC	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation rewiring degron network	0.3056
p.D52N	DO218861	SKCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1389
p.D57N	DO218847	SKCA	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.2778
p.P49L	DO38795	STAD	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0556
p.D52Y	DO219777	UCEC	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1389
p.A62P	DO42113	UCEC	ICGC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation altering degron motif	0.7503
p.G390R	SIDM00722	Mesothelioma	GDSC	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation altering degron motif	0.7568
p.G390R	ACH-000092	Lung Cancer	CCLE	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation altering degron motif	0.7568
p.G390R	NCI-H2452	pleura	COSMIC	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation altering degron motif	0.7568
p.T56M	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.T56M	SIDM00690	Head and Neck Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.T56M	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.T56M	SIDM00628	Breast Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.T56M	SIDM01318	Hepatocellular Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.T56M	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.T56M	SIDM01752	Pancreatic Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.T56M	SIDM01525	Acute Myeloid Leukemia	GDSC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.25
p.S381P	SIDM01112	Osteosarcoma	GDSC	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation altering degron motif	0.7863
p.S381P	SJSA-1	bone	COSMIC	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation altering degron motif	0.7863
p.T67M	SIDM00032	Bladder Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.2222
p.L50F	ACH-000283	Brain Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0833
p.L50F	ACH-000853	Lung Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0833
p.L50F	NCI-H661	lung	COSMIC	VATSS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0833
p.E400K	HT-3	cervix	COSMIC	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation rewiring degron network	0.0833
p.E400K	OVK-18	ovary	COSMIC	SVKEDSVPTGA	DEG_COP1_1	381:391	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BCAS1

UniProt ID: O75363

Entrez ID: 8537

Protein name: Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BCAS1 in