DegronMD

Uniprot ID: O75363

Source protein: Breast carcinoma-amplified sequence 1

Source gene: BCAS1

Class: DEG_COP1_1

Location: 381:391

E3 ligase: COP1

DEGRON score: 0.9932

ASA_SCORE: 96.8636

COIL: 0.9333

CONS_SCORE: 0.8466

DSS_SCORE: 0.4201

HELIX: 0.037

FCONS_SCORE: 0.9233

RIG_SCORE: 0.7206

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S386L	TCGA-12-3646	GBM	TCGA	SVKEDSVPTGA	DEG_COP1_1	0.7667
p.S386L	DO12184	GBM	ICGC	SVKEDSVPTGA	DEG_COP1_1	0.7667
p.E393D	TCGA-30-1853	OV	TCGA	SVKEDSVPTGA	DEG_COP1_1	0.2778
p.E393D	DO28002	OV	ICGC	SVKEDSVPTGA	DEG_COP1_1	0.2778
p.E393D	SIDM00425	Ovarian Carcinoma	GDSC	SVKEDSVPTGA	DEG_COP1_1	0.2778
p.E393D	ACH-000663	Ovarian Cancer	CCLE	SVKEDSVPTGA	DEG_COP1_1	0.2778
p.E393D	OVTOKO	ovary	COSMIC	SVKEDSVPTGA	DEG_COP1_1	0.2778
p.D385H	TCGA-44-2656	LUAD	TCGA	SVKEDSVPTGA	DEG_COP1_1	0.6577
p.D385H	DO26052	LUAD	ICGC	SVKEDSVPTGA	DEG_COP1_1	0.6577
p.S399P	TCGA-A7-A0D9	BRCA	TCGA	SVKEDSVPTGA	DEG_COP1_1	0.5556
p.S399P	DO4128	BRCA	ICGC	SVKEDSVPTGA	DEG_COP1_1	0.5556
p.E392K	TCGA-FS-A1ZC	SKCM	TCGA	SVKEDSVPTGA	DEG_COP1_1	0.3056
p.E392K	TCGA-FW-A3R5	SKCM	TCGA	SVKEDSVPTGA	DEG_COP1_1	0.3056
p.E392K	DO37406	SKCM	ICGC	SVKEDSVPTGA	DEG_COP1_1	0.3056
p.E392K	DO37487	SKCM	ICGC	SVKEDSVPTGA	DEG_COP1_1	0.3056
p.K380R	DO33091	PACA	ICGC	SVKEDSVPTGA	DEG_COP1_1	0.3056
p.G390R	SIDM00722	Mesothelioma	GDSC	SVKEDSVPTGA	DEG_COP1_1	0.7568
p.G390R	ACH-000092	Lung Cancer	CCLE	SVKEDSVPTGA	DEG_COP1_1	0.7568
p.G390R	NCI-H2452	pleura	COSMIC	SVKEDSVPTGA	DEG_COP1_1	0.7568
p.S381P	SIDM01112	Osteosarcoma	GDSC	SVKEDSVPTGA	DEG_COP1_1	0.7863
p.S381P	SJSA-1	bone	COSMIC	SVKEDSVPTGA	DEG_COP1_1	0.7863
p.E400K	HT-3	cervix	COSMIC	SVKEDSVPTGA	DEG_COP1_1	0.0833
p.E400K	OVK-18	ovary	COSMIC	SVKEDSVPTGA	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75363	Breast carcinoma-amplified sequence 1	DEG_COP1_1	381:391	SVKEDSVPTGA	COP1	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons