DegronMD

Uniprot ID: P49750

Source protein: YLP motif-containing protein 1

Source gene: YLPM1

Class: DEG_SPOP_SBC_1

Location: 971:975

E3 ligase: SPOP

DEGRON score: 0.9823

ASA_SCORE: 78.06

COIL: 0.9234

CONS_SCORE: 0.3866

DSS_SCORE: 0.5452

HELIX: 0.0304

FCONS_SCORE: 1.061

RIG_SCORE: 0.7298

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S974L	TCGA-53-7626	LUAD	TCGA	VATSS	DEG_SPOP_SBC_1	0.7667
p.S974L	DO23774	LUAD	ICGC	VATSS	DEG_SPOP_SBC_1	0.7667
p.A970P	TCGA-AG-3725	READ	TCGA	VATSS	DEG_SPOP_SBC_1	0.3056
p.A970P	DO36745	READ	ICGC	VATSS	DEG_SPOP_SBC_1	0.3056
p.G968A	TCGA-HD-8634	HNSC	TCGA	VATSS	DEG_SPOP_SBC_1	0.25
p.G968A	DO14196	HNSC	ICGC	VATSS	DEG_SPOP_SBC_1	0.25
p.D981Y	DO222884	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	0.1667
p.A972P	DO231169	LUSC	ICGC	VATSS	DEG_SPOP_SBC_1	0.6392
p.G964W	SIDM01279	Colorectal Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.1389
p.A970V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VATSS	DEG_SPOP_SBC_1	0.3056
p.A970V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VATSS	DEG_SPOP_SBC_1	0.3056
p.A970V	ACH-000995	Leukemia	CCLE	VATSS	DEG_SPOP_SBC_1	0.3056
p.A970V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	0.3056
p.G964A	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.1389
p.G964A	SIDM01664	Prostate Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.1389
p.D981H	SIDM00449	B-Lymphoblastic Leukemia	GDSC	VATSS	DEG_SPOP_SBC_1	0.1667
p.D981H	ACH-000922	Leukemia	CCLE	VATSS	DEG_SPOP_SBC_1	0.1667
p.D981H	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	0.1667
p.N980S	SIDM01182	Bladder Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	0.1944
p.N980S	ACH-000522	Bladder Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	0.1944
p.N980S	UM-UC-3	urinary_tract	COSMIC	VATSS	DEG_SPOP_SBC_1	0.1944
p.R977H	ACH-000965	Endometrial/Uterine Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	0.2778
p.R977H	RL95-2	endometrium	COSMIC	VATSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94991	SLIT and NTRK-like protein 5	DEG_SPOP_SBC_1	316:320	VATSS	SPOP	0.5471	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1761:1765	VATSS	SPOP	0.9537	More...
P46821	Microtubule-associated protein 1B	DEG_SPOP_SBC_1	1557:1561	VATSS	SPOP	0.8877	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	971:975	VATSS	SPOP	0.9823	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	921:925	VATSS	SPOP	0.9219	More...
Q96CT7	Coiled-coil domain-containing protein 124	DEG_SPOP_SBC_1	89:93	VATSS	SPOP	0.9938	More...
Q9H1A4	Anaphase-promoting complex subunit 1	DEG_SPOP_SBC_1	295:299	VATSS	SPOP	0.8406	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SPOP_SBC_1	1484:1488	VATSS	SPOP	0.8289	More...
O43638	Forkhead box protein S1	DEG_SPOP_SBC_1	208:212	VATSS	SPOP	0.8893	More...
O75363	Breast carcinoma-amplified sequence 1	DEG_SPOP_SBC_1	59:63	VATSS	SPOP	0.9947	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	461:465	VATSS	SPOP	0.9974	More...
Q6UX68	XK-related protein 5	DEG_SPOP_SBC_1	550:554	VATSS	SPOP	0.9819	More...
Q9BTE0	Alpha/beta-tubulin-N-acetyltransferase 9	DEG_SPOP_SBC_1	164:168	VATSS	SPOP	0.7158	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons