DegronMD - P49750(YLPM1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G861R	TCGA-50-5941	LUAD	TCGA	ADTSS	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.1667
p.G861R	DO25528	LUAD	ICGC	ADTSS	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.1667
p.S974L	TCGA-53-7626	LUAD	TCGA	VATSS	DEG_SPOP_SBC_1	971:975	Mutation altering degron motif	0.7667
p.S974L	DO23774	LUAD	ICGC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation altering degron motif	0.7667
p.R814L	TCGA-66-2795	LUSC	TCGA	ITPSTS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.1111
p.R814L	DO26710	LUSC	ICGC	ITPSTS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.1111
p.K875N	TCGA-AA-3984	COAD	TCGA	ADTSS	DEG_SPOP_SBC_1	867:871	Mutation blocking ubiquitination signal	0.6667
p.K875N	DO9002	COAD	ICGC	ADTSS	DEG_SPOP_SBC_1	867:871	Mutation blocking ubiquitination signal	0.6667
p.A970P	TCGA-AG-3725	READ	TCGA	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.3056
p.A970P	DO36745	READ	ICGC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.3056
p.Q819R	TCGA-B5-A1MX	UCEC	TCGA	ITPSTS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.25
p.Q819R	DO41999	UCEC	ICGC	ITPSTS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.25
p.P830S	TCGA-B6-A0RM	BRCA	TCGA	ITPSTS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.25
p.P830S	DO3128	BRCA	ICGC	ITPSTS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.25
p.P171T	TCGA-CM-5861	COAD	TCGA	PPSY	ITCH	171:174	Mutation altering degron motif	0.7031
p.P171T	DO7918	COAD	ICGC	PPSY	ITCH	171:174	Mutation altering degron motif	0.7031
p.R814Q	TCGA-CV-6945	HNSC	TCGA	ITPSTS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.1111
p.R814Q	DO15767	HNSC	ICGC	ITPSTS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.1111
p.P177Q	TCGA-D9-A1X3	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.5924
p.P177Q	DO37456	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.5924
p.P177S	TCGA-D9-A6EC	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.5641
p.P177S	DO50291	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.5641
p.S173Y	TCGA-EO-A22R	UCEC	TCGA	PPSY	ITCH	171:174	Mutation altering degron motif	0.6009
p.S173Y	DO42713	UCEC	ICGC	PPSY	ITCH	171:174	Mutation altering degron motif	0.6009
p.G968A	TCGA-HD-8634	HNSC	TCGA	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.25
p.G968A	DO14196	HNSC	ICGC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.25
p.S190C	TCGA-K4-A3WS	BLCA	TCGA	PPTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.0556
p.S190C	DO480	BLCA	ICGC	PPTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.0556
p.A202V	DO222794	COCA	ICGC	LAPTPSYS	DEG_SCF_FBW7_1	201:208	Mutation altering degron motif	0.5825
p.D981Y	DO222884	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.1667
p.S180Y	DO222884	COCA	ICGC	PPTSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.712
p.P186S	DO229050	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1667
p.H57R	DO23545	LIRI	ICGC	APSSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.0833
p.A972P	DO231169	LUSC	ICGC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation altering degron motif	0.6392
p.Y175S	DO228550	MALY	ICGC	PPTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.3056
p.Y175S	DO228550	MALY	ICGC	PPSY	ITCH	171:174	Mutation rewiring degron network	0.3056
p.P189L	DO33077	PACA	ICGC	PPTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.0833
p.G964W	SIDM01279	Colorectal Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.1389
p.A970V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.3056
p.A970V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.3056
p.A970V	ACH-000995	Leukemia	CCLE	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.3056
p.A970V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.3056
p.G964A	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.1389
p.G964A	SIDM01664	Prostate Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.1389
p.D981H	SIDM00449	B-Lymphoblastic Leukemia	GDSC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.1667
p.D981H	ACH-000922	Leukemia	CCLE	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.1667
p.D981H	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.1667
p.Q873E	SIDM01060	Melanoma	GDSC	ADTSS	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2778
p.Q873E	ACH-000882	Skin Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2778
p.Q873E	IGR-1	skin	COSMIC	ADTSS	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2778
p.M51I	SIDM00963	Breast Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.25
p.M51I	ACH-000927	Breast Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.25
p.G49S	SIDM00199	Chondrosarcoma	GDSC	APSSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.3056
p.G49S	ACH-002099	Bone Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.3056
p.G49S	CS1	bone	COSMIC	APSSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.3056
p.N980S	SIDM01182	Bladder Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.1944
p.N980S	ACH-000522	Bladder Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.1944
p.N980S	UM-UC-3	urinary tract	COSMIC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.1944
p.R977H	ACH-000965	Endometrial/Uterine Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.2778
p.R977H	RL95-2	endometrium	COSMIC	VATSS	DEG_SPOP_SBC_1	971:975	Mutation rewiring degron network	0.2778
p.D869V	ACH-000978	Endometrial/Uterine Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	867:871	Mutation altering degron motif	0.7785
p.D869V	EN	endometrium	COSMIC	ADTSS	DEG_SPOP_SBC_1	867:871	Mutation altering degron motif	0.7785
p.S872Y	ACH-000991	Colon/Colorectal Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.3056
p.S872Y	SNU-81	large intestine	COSMIC	ADTSS	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.3056
p.S190P	EVSA-T	breast	COSMIC	PPTSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

YLPM1

UniProt ID: P49750

Entrez ID: 56252

Protein name: YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for YLPM1 in