DegronMD

Uniprot ID: P49750

Source protein: YLP motif-containing protein 1

Source gene: YLPM1

Class: DEG_SCF_FBW7_1

Location: 822:827

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 75.4167

COIL: 0.937

CONS_SCORE: 0.4119

DSS_SCORE: 0.6782

HELIX: 0.0447

FCONS_SCORE: 1.1202

RIG_SCORE: 0.6964

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R814L	TCGA-66-2795	LUSC	TCGA	ITPSTS	DEG_SCF_FBW7_1	0.1111
p.R814L	DO26710	LUSC	ICGC	ITPSTS	DEG_SCF_FBW7_1	0.1111
p.Q819R	TCGA-B5-A1MX	UCEC	TCGA	ITPSTS	DEG_SCF_FBW7_1	0.25
p.Q819R	DO41999	UCEC	ICGC	ITPSTS	DEG_SCF_FBW7_1	0.25
p.P830S	TCGA-B6-A0RM	BRCA	TCGA	ITPSTS	DEG_SCF_FBW7_1	0.25
p.P830S	DO3128	BRCA	ICGC	ITPSTS	DEG_SCF_FBW7_1	0.25
p.R814Q	TCGA-CV-6945	HNSC	TCGA	ITPSTS	DEG_SCF_FBW7_1	0.1111
p.R814Q	DO15767	HNSC	ICGC	ITPSTS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49750	YLP motif-containing protein 1	DEG_SCF_FBW7_1	822:827	ITPSTS	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons