DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LAPTPSYS
Uniprot ID:
P49750
Source protein:
YLP motif-containing protein 1
Source gene:
YLPM1
Class:
DEG_SCF_FBW7_1
Location:
201:208
E3 ligase:
FBXW7
DEGRON score:
0.9717
ASA_SCORE:
92.0125
COIL:
0.9649
CONS_SCORE:
0.2145
DSS_SCORE:
0.5999
HELIX:
0.0181
FCONS_SCORE:
0.941
RIG_SCORE:
0.5654
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A202V
DO222794
COCA
ICGC
LAPTPSYS
DEG_SCF_FBW7_1
0.5825
Drug responses associated with YLPM1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LAPTPSYS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P49750
YLP motif-containing protein 1
DEG_SCF_FBW7_1
201:208
LAPTPSYS
FBXW7
0.9717
More...