DegronMD - Q96KR1(ZFR)

FUNCTION: Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity). {ECO:0000250}.

GO - Biological processes (BP):

GO - Molecular function (MF): DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]

GO - Cellular component (CC): chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P530H	DO228948	LICA	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation altering degron motif	0.7694
p.T458M	TCGA-A5-A0G2	UCEC	TCGA	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation altering degron motif	0.7423
p.T458M	TCGA-HU-A4G8	STAD	TCGA	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation altering degron motif	0.7423
p.T458M	DO47819	STAD	ICGC	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation altering degron motif	0.7423
p.T458M	DO41235	UCEC	ICGC	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation altering degron motif	0.7423
p.T463M	DO230336	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation altering degron motif	0.7423
p.T222I	TCGA-D3-A2JF	SKCM	TCGA	PATTT	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.7078
p.T222I	DO38153	SKCM	ICGC	PATTT	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.7078
p.V461I	DO229010	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation altering degron motif	0.7076
p.V461I	DO229013	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation altering degron motif	0.7076
p.V461I	DO229016	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation altering degron motif	0.7076
p.V461I	DO229003	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation altering degron motif	0.7076
p.V461I	DO229005	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation altering degron motif	0.7076
p.V461I	DO228941	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation altering degron motif	0.7076
p.T222S	SIDM00733	Small Cell Lung Carcinoma	GDSC	PATTT	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.6005
p.T222S	ACH-000525	Lung Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.6005
p.T222S	NCI-H2171	lung	COSMIC	PATTT	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.6005
p.N457S	TCGA-A5-A1OF	UCEC	TCGA	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation altering degron motif	0.5958
p.N457S	DO42568	UCEC	ICGC	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation altering degron motif	0.5958
p.S475L	TCGA-AP-A1DV	UCEC	TCGA	VATSS	DEG_SPOP_SBC_1	461:465	Mutation blocking phosphorylation signal	0.5

Showing 1 to 20 of 75 entries

Previous1 2 3 4Next

Kaplan plot for ZFR in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFR

UniProt ID: Q96KR1

Entrez ID: 51663

Protein name: Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZFR in