DegronMD - Q96KR1(ZFR)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S440L	TCGA-A4-7583	KIRP	TCGA	ATSST	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1944
p.S440L	DO20870	KIRP	ICGC	ATSST	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1944
p.T458M	TCGA-A5-A0G2	UCEC	TCGA	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation altering degron motif	0.7423
p.T458M	TCGA-HU-A4G8	STAD	TCGA	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation altering degron motif	0.7423
p.T458M	DO47819	STAD	ICGC	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation altering degron motif	0.7423
p.T458M	DO41235	UCEC	ICGC	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation altering degron motif	0.7423
p.N457S	TCGA-A5-A1OF	UCEC	TCGA	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation altering degron motif	0.5958
p.N457S	DO42568	UCEC	ICGC	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation altering degron motif	0.5958
p.S226F	TCGA-AJ-A3BH	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.2778
p.S226F	TCGA-AJ-A3BH	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.25
p.S226F	DO41638	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.2778
p.S226F	DO41638	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.25
p.I449S	TCGA-AJ-A3EK	UCEC	TCGA	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.1389
p.I449S	DO41584	UCEC	ICGC	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.1389
p.S475L	TCGA-AP-A1DV	UCEC	TCGA	VATSS	DEG_SPOP_SBC_1	461:465	Mutation blocking phosphorylation signal	0.5
p.S475L	DO43186	UCEC	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation blocking phosphorylation signal	0.5
p.D543E	TCGA-AX-A06F	UCEC	TCGA	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.0556
p.D543E	DO41752	UCEC	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.0556
p.P421T	TCGA-AX-A2HC	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0556
p.P421T	DO41572	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0556
p.A439V	TCGA-BH-A0HF	BRCA	TCGA	ATSST	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.2222
p.A439V	DO1749	BRCA	ICGC	ATSST	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.2222
p.E524K	TCGA-CL-5917	READ	TCGA	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.2778
p.E524K	TCGA-E6-A1M0	UCEC	TCGA	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.2778
p.E524K	DO36560	READ	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.2778
p.E524K	DO43682	UCEC	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.2778
p.T222I	TCGA-D3-A2JF	SKCM	TCGA	PATTT	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.7078
p.T222I	DO38153	SKCM	ICGC	PATTT	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.7078
p.P421L	TCGA-DD-AADK	LIHC	TCGA	ATSST	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0556
p.P421L	DO52235	LIHC	ICGC	ATSST	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0556
p.P538S	TCGA-E6-A1LX	UCEC	TCGA	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.1944
p.P538S	DO41020	UCEC	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.1944
p.V540G	TCGA-G2-AA3B	BLCA	TCGA	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.1389
p.V540G	DO51882	BLCA	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.1389
p.E539K	TCGA-KQ-A41R	BLCA	TCGA	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.1667
p.E539K	DO223592	BLCA	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.1667
p.I520T	DO228483	BRCA	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.1667
p.I520T	DO229005	COCA	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.1667
p.I520T	DO229047	LICA	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.1667
p.I520T	DO230550	LUSC	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.1667
p.A444L	DO223508	CLLE	ICGC	ATSST	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.0833
p.T463M	DO230336	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation altering degron motif	0.7423
p.V461I	DO229010	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation altering degron motif	0.7076
p.V461I	DO229013	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation altering degron motif	0.7076
p.V461I	DO229016	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation altering degron motif	0.7076
p.V461I	DO229003	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation altering degron motif	0.7076
p.V461I	DO229005	COCA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation altering degron motif	0.7076
p.V461I	DO228941	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation altering degron motif	0.7076
p.T470M	DO234400	ESAD	ICGC	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.0556
p.T470M	DO234400	ESAD	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation rewiring degron network	0.1944
p.P530H	DO228948	LICA	ICGC	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation altering degron motif	0.7694
p.T472K	DO228948	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation rewiring degron network	0.1389
p.P236Q	DO228986	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.25
p.P218T	DO229038	LICA	ICGC	PATTT	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.2778
p.A451E	DO229038	LICA	ICGC	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.1944
p.A451E	DO229038	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	461:465	Mutation rewiring degron network	0.0556
p.A450E	DO229037	LICA	ICGC	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.1667
p.P425Q	DO229008	LICA	ICGC	ATSST	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1667
p.V234A	DO45049	LINC	ICGC	PATTT	DEG_SPOP_SBC_1	220:224	Mutation rewiring degron network	0.0556
p.V234A	DO45049	LINC	ICGC	PVSST	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.3056
p.K214N	DO219881	SKCA	ICGC	PATTT	DEG_SPOP_SBC_1	220:224	Mutation substituting flanking lysine	0.2778
p.D543N	SIDM00572	Gastric Carcinoma	GDSC	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.0556
p.D543N	ACH-000911	Gastric Cancer	CCLE	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.0556
p.D543N	NUGC-3	stomach	COSMIC	VKSTPVTS	DEG_SCF_FBW7_1	526:533	Mutation rewiring degron network	0.0556
p.N426T	SIDM00741	Small Cell Lung Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1944
p.N426T	ACH-000431	Lung Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1944
p.N426T	NCI-H1694	lung	COSMIC	ATSST	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.1944
p.T222S	SIDM00733	Small Cell Lung Carcinoma	GDSC	PATTT	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.6005
p.T222S	ACH-000525	Lung Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.6005
p.T222S	NCI-H2171	lung	COSMIC	PATTT	DEG_SPOP_SBC_1	220:224	Mutation altering degron motif	0.6005
p.S447P	SIDM00685	Glioblastoma	GDSC	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.0833
p.S447P	ACH-000819	Brain Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.0833
p.S447P	LN-18	central nervous system	COSMIC	VNTSS	DEG_SPOP_SBC_1	456:460	Mutation rewiring degron network	0.0833
p.A436T	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.3056
p.A436T	ACH-000925	Lung Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	431:435	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFR

UniProt ID: Q96KR1

Entrez ID: 51663

Protein name: Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZFR in