DegronMD

Uniprot ID: Q96KR1

Source protein: Zinc finger RNA-binding protein

Source gene: ZFR

Class: DEG_SPOP_SBC_1

Location: 456:460

E3 ligase: SPOP

DEGRON score: 0.7805

ASA_SCORE: 69.04

COIL: 0.5566

CONS_SCORE: 0.2099

DSS_SCORE: 0.3873

HELIX: 0.0498

FCONS_SCORE: 0.8293

RIG_SCORE: 0.7336

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T458M	TCGA-A5-A0G2	UCEC	TCGA	VNTSS	DEG_SPOP_SBC_1	0.7423
p.T458M	TCGA-HU-A4G8	STAD	TCGA	VNTSS	DEG_SPOP_SBC_1	0.7423
p.T458M	DO47819	STAD	ICGC	VNTSS	DEG_SPOP_SBC_1	0.7423
p.T458M	DO41235	UCEC	ICGC	VNTSS	DEG_SPOP_SBC_1	0.7423
p.N457S	TCGA-A5-A1OF	UCEC	TCGA	VNTSS	DEG_SPOP_SBC_1	0.5958
p.N457S	DO42568	UCEC	ICGC	VNTSS	DEG_SPOP_SBC_1	0.5958
p.I449S	TCGA-AJ-A3EK	UCEC	TCGA	VNTSS	DEG_SPOP_SBC_1	0.1389
p.I449S	DO41584	UCEC	ICGC	VNTSS	DEG_SPOP_SBC_1	0.1389
p.T470M	DO234400	ESAD	ICGC	VNTSS	DEG_SPOP_SBC_1	0.0556
p.A451E	DO229038	LICA	ICGC	VNTSS	DEG_SPOP_SBC_1	0.1944
p.A450E	DO229037	LICA	ICGC	VNTSS	DEG_SPOP_SBC_1	0.1667
p.S447P	SIDM00685	Glioblastoma	GDSC	VNTSS	DEG_SPOP_SBC_1	0.0833
p.S447P	ACH-000819	Brain Cancer	CCLE	VNTSS	DEG_SPOP_SBC_1	0.0833
p.S447P	LN-18	central_nervous_system	COSMIC	VNTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P09619	Platelet-derived growth factor receptor beta	DEG_SPOP_SBC_1	1052:1056	VNTSS	SPOP	0.9079	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	369:373	VNTSS	SPOP	0.9386	More...
Q8TAX7	Mucin-7	DEG_SPOP_SBC_1	145:149	VNTSS	SPOP	0.9158	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	221:225	VNTSS	SPOP	0.9787	More...
Q9H6R7	WD repeat and coiled-coil-containing protein	DEG_SPOP_SBC_1	482:486	VNTSS	SPOP	0.7588	More...
O94913	Pre-mRNA cleavage complex 2 protein Pcf11	DEG_SPOP_SBC_1	154:158	VNTSS	SPOP	0.9935	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	456:460	VNTSS	SPOP	0.7805	More...
Q6Q759	Sperm-associated antigen 17	DEG_SPOP_SBC_1	11:15	VNTSS	SPOP	0.8744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons